ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE tablet

Страна: Соединенные Штаты

Язык: английский

Источник: NLM (National Library of Medicine)

Активный ингредиент:

ENALAPRIL MALEATE (UNII: 9O25354EPJ) (ENALAPRILAT ANHYDROUS - UNII:Q508Q118JM)

Доступна с:

Lake Erie Medical DBA Quality Care Products LLC

ИНН (Международная Имя):

ENALAPRIL MALEATE

состав:

ENALAPRIL MALEATE 10 mg

Тип рецепта:

PRESCRIPTION DRUG

Статус Авторизация:

Abbreviated New Drug Application

Характеристики продукта

ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE- ENALAPRIL MALEATE AND
HYDROCHLOROTHIAZIDE TABLET
LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC
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USE IN PREGNANCY
WHEN USED IN PREGNANCY DURING THE SECOND AND THIRD TRIMESTERS, ACE
INHIBITORS CAN CAUSE
INJURY AND EVEN DEATH TO THE DEVELOPING FETUS. When pregnancy is
detected, enalapril maleate
and hydrochlorothiazide tablets should be discontinued as soon as
possible (see WARNINGS:
_Pregnancy, Enalapril Maleate, Fetal/Neonatal Morbidity and
Mortality)_.
DESCRIPTION
Enalapril maleate and hydrochlorothiazide
Enalapril maleate is the maleate salt of enalapril, the ethyl ester of
a long-acting angiotensin converting
enzyme inhibitor, enalaprilat. Enalapril maleate is chemically
described as (_S_)-1-[_N_-[1-
(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline,
(_Z_)-2-butenedioate salt (1:1). Its empirical
formula is C
H N O •C H O , and its structural formula is:
Enalapril maleate is a white to off-white crystalline powder with a
molecular weight of 492.52. It is
sparingly soluble in water, soluble in ethanol, and freely soluble in
methanol.
Enalapril is a pro-drug; following oral administration, it is
bioactivated by hydrolysis of the ethyl ester
to enalaprilat, which is the active angiotensin converting enzyme
inhibitor.
Hydrochlorothiazide is
6-chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7-sulfonamide
1,1-dioxide.
Its empirical formula is C H ClN O S and its structural formula is:
It is a white, or practically white, crystalline powder with a
molecular weight of 297.74, which is
slightly soluble in water, but freely soluble in sodium hydroxide
solution.
Enalapril Maleate and Hydrochlorothiazide is available in two tablet
combinations of enalapril maleate
with hydrochlorothiazide: Enalapril Maleate and Hydrochlorothiazide
Tablets 5/12.5, containing 5 mg
enalapril maleate and 12.5 mg hydrochlorothiazide and Enalapril
Maleate and Hydrochlorothiazide
Tablets 10/25, containing 10 mg enalapril maleate and 25 mg
hydrochlorothiazide. Inactive ingredients
combines