DYNAVATE-N CREAM

Страна: Малайзия

Язык: английский

Источник: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Активный ингредиент:

BETAMETHASONE; NEOMYCIN SULPHATE

Доступна с:

DYNAPHARM (M) SDN BHD

ИНН (Международная Имя):

BETAMETHASONE; NEOMYCIN SULPHATE

Штук в упаковке:

15 gm

Производитель:

DYNAPHARM (M) SDN BHD

тонкая брошюра

Consumer Medication Information Leaflet (RiMUP)
DYNAVATE-N CREAM
Betamethasone-17-Valerate / Neomycin Sulphate (0.1% / 0.5%)
1
What is in this leaflet
1.
What Dynavate-N Cream is used for
2.
How Dynavate-N Cream works
3.
Before you use Dynavate-N Cream
4.
How to use Dynavate-N Cream
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Dynavate-N
Cream
8.
Product Description
9.
Manufacturer and Product
Registration Holder
10.
Date of revision
What Dynavate-N Cream is used for
Inflammatory skin disease responsive to
medications which are applied directly to
the skin, when bacterial infection is
present or suspected.
How Dynavate-N Cream works
It is responsible for anti-inflammatory
effects to topical application of
corticosteroid.
Before you use Dynavate-N Cream
-
When you must not use it
Do not use this cream if:
-
Skin diseases
-
Acne
-
Inflammation around mouth
-
Viral infections (such as herpes
simplex, chickenpox).
-
Hypersensitivity to the preparation.
-
In the treatment of skin changes due to
disease caused by infection with fungi
or bacteria.
-
Infections due to yeast.
-
Skin disease in children under 1 year of
age, including dermatitis and napkin
eruptions.
Pregnancy and lactation
Do not take Dynavate-N Cream if you
are pregnant, trying to get pregnant or
think you may be pregnant.
Do not take Dynavate-N Cream if you
are breast-feeding. Ask your doctor or
pharmacist for advice before taking any
medicine.
-
Before you start use it
Preparations containing neomycin should
not be used for the treatment of otitis
externa (condition that causes
inflammation (redness and swelling) of
the external ear canal) when the ear drum
is perforated, because of the risk of
ototoxicity (loss of hearing).
-
Taking other medicines
Tell your doctor if you are taking any
other medicines, including any that you
buy without a prescription from a
pharmacy, supermarket or health food
shop.
How to use Dynavate-N Cream
-
How much to use
Apply thinly, to the affected parts, two to
three times daily.
Follow all direction

Характеристики продукта

DYNAVATE-N CREAM
MAL19950248AZ
DESCRIPTION:
CREAM
Colour
:
White
Fragrance
:
Baby Jo
CONTENT:
Betamethasone 17-Valerate equivalent to Betamethasone .... 0.1% w/w
Neomycin Sulphate ....................................................
0.5% w/w
(Preservative: Chlorocresol 0.1% w/w)
PHARMACODYNAMICS:
Corticosteroids diffuse across cell membranes and complex with
specific cytoplasmic receptors. These complexes then enter the cell
nucleus, bind to DNA and stimulate transcription of messenger RNA
(mRNA) and subsequent protein synthesis of various enzymes
thought to be ultimately responsible for anti-inflammatory effects to
topical application of corticosteroid. Neomycin and other
aminoglycoside antibiotics interfere with bacterial protein synthesis
by binding primarily to the 30S sub-unit of bacterial ribosomes.
PHARMACOKINETICS:
Corticosteroids in the circulation are extensively bound to plasma
proteins, mainly to globulin and less so to albumin. The
corticosteroid-binding globulin has high affinity but low binding
capacity, which the albumin has low affinity but large binding
capacity. Only unbound corticosteroid has pharmacological effects or
is metabolised. Corticosteroids are metabolised mainly in the
liver but also in the kidney, and are excreted in the urine. The
slower metabolism of the synthetic corticosteroids with their lower
protein-binding affinity may account for their increased potency
compared with the natural corticosteroids.
Neomycin is poorly absorbed from the alimentary tract, about 97% of an
orally administered dose being excreted unchanged in the
faeces. Doses of 3 g by mouth produce peak plasma concentrations of up
to 4 µg/ml and absorption is similar after administration by
enema. Absorption has also been reported to occur from the peritoneum,
respiratory tract, bladder, wounds, and inflammed skin.
Once neomycin is absorbed it is rapidly excreted by the kidneys in the
active form. It has been reported to have a half-life of 2 to 3
hours.
INDICATION:
Inflammatory dermatoses responsive to topical