DOMOSO dimethyl sulfoxide solution

Страна: Соединенные Штаты

Язык: английский

Источник: NLM (National Library of Medicine)

Активный ингредиент:

dimethyl sulfoxide (UNII: YOW8V9698H) (dimethyl sulfoxide - UNII:YOW8V9698H)

Доступна с:

Zoetis Inc.

ИНН (Международная Имя):

dimethyl sulfoxide

состав:

dimethyl sulfoxide 90 g in 100 mL

Тип рецепта:

PRESCRIPTION

Статус Авторизация:

New Animal Drug Application

Характеристики продукта

DOMOSO- DIMETHYL SULFOXIDE SOLUTION
ZOETIS INC.
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DOMOS O
(DIMETHYL SULFOXIDE)
SOLUTION
90% Dimethyl Sulfoxide — Medical Grade
For Animal Use Only
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
GENERAL
Dimethyl sulfoxide (DMSO), an oxidation product of dimethyl sulfide,
is an exceptional solvent
possessing a number of commercial uses.
DMSO is the lowest member of the group of alkyl sulfoxides with a
general formula of RSOR. Its
structural formula is:
It freely mixes with water with the evolution of heat and lowers the
freezing point of aqueous solutions.
It is soluble in many other compounds including ethanol, acetone,
diethyl ether, glycerin, toluene,
benzene and chloroform. DMSO is a solvent for many aromatic and
unsaturated hydrocarbons as well as
inorganic salts and nitrogen-containing compounds. DMSO has a high
dielectric constant due to the
polarity of the sulfur-oxygen bond. Its basicity is slightly greater
than water due to enhanced electron
density at the oxygen atom. It forms crystalline salts with strong
protic acids and coordinates with Lewis
acids. It modifies hydrogen bonding.
DMSO is a hygroscopic stable organic liquid essentially odorless and
water white in color. Other
physical characteristics include:
Molecular weight
78.13
Melting point
18.45°C
Boiling point
189°C
Each mL of DOMOSO (dimethyl sulfoxide) Solution contains 90% dimethyl
sulfoxide and 10% water.
METABOLISM
Dimethyl sulfoxide when administered topically or orally is rapidly
absorbed and distributed in living
material.
Using S
-labeled DMSO (1) the maximal blood concentration after cutaneous
application was achieved
®
35
in approximately 10 minutes in rats and less than 1 hour in dogs. In
rats and dogs the substance did not
accumulate in the organs but the concentration in the treated skin and
underlying muscle was increased.
The main route of excretion is via the urine partially dependent on
the species and route of application.
In rats there was no significant difference i