DEXAMETHASONE SOLUTION- dexamethasone solution

Страна: Соединенные Штаты

Язык: английский

Источник: NLM (National Library of Medicine)

Активный ингредиент:

Dexamethasone (UNII: 7S5I7G3JQL) (Dexamethasone - UNII:7S5I7G3JQL)

Доступна с:

MWI/VetOne

Тип рецепта:

PRESCRIPTION

Терапевтические показания :

INDICATIONS : Dexamethasone is indicated for the treatment of primary bovine ketosis and as an anti-inflammatory agent in the bovine and equine. As supportive therapy, Dexamethasone may be used in the management of various rheumatic, allergic, dermatologic, and other diseases known to be responsive to anti-inflammatory corticosteroids.  Dexamethasone may be used intravenously as supportive therapy when an immediate hormonal response is required. Bovine Ketosis Dexamethasone is offered for the treatment of primary ketosis.  The gluconeogenic effects of Dexamethasone, when administered intramuscularly, are generally noted within the first 6 to 12 hours.  When Dexamethasone is used intravenously, the effects may be noted sooner.  Blood sugar levels rise to normal levels within 12 to 24 hours.  Acetone bodies are reduced to normal concentrations usually within 24 hours.  The physical attitude of animals treated with Dexamethasone brightens and appetite improves, usually within 12 hours.  Milk production, which is

Обзор продуктов:

HOW SUPPLIED : Dexamethasone, 2mg per mL, 100mL multiple dose vial.

Статус Авторизация:

Abbreviated New Animal Drug Application

Характеристики продукта

DEXAMETHASONE SOLUTION- DEXAMETHASONE SOLUTION
MWI/VETONE
----------
MWI/VETONE DEXAMETHASONE 2MG INJECTION (DEXAMETHASONE SOLUTION) ANADA
200-312
CAUTION: Federal law restricts this drug to use by or on the order of
a licensed veterinarian.
DESCRIPTION: Dexamethasone Solution is a synthetic analogue of
prednisolone, having similar but
more potent anti-inflammatory therapuetic action and diversified
hormonal and metabolic effects.
Modification of the basic corticoid structure as achieved in
Dexamethasone offers enhanced anti-
inflammatory effect compared to older corticosteroids. The dosage of
Dexamethasone required is
markedly lower than that of prednisone and prednisolone.
Dexamethasone is not species-specific; however, the veterinarian
should read the sections on
INDICATIONS, DOSAGE, SIDE EFFECTS, CONTRAINDICATIONS, PRECAUTIONS, and
WARNINGS before this drug is used. Dexamethasone is intended for
intravenous or intramuscular
adiminstration.
Each mL contains 2 mg dexamethasone, 500 mg polylethylene glycol 400,
9 mg benzyl alcohol, 1.8 mg
methylparaben and 0.2 mg propylparaben as preservatives, 4.75%
alcohol, HCl to adjust pH to
approximately 4.9, water for injection q.s.
EXPERIMENTAL STUDIES: Experimental animal studies on dexamethasone
have revealed it
possesses greater anti-inflammatory activity than many steroids.
Veterinary clinical evidence indicates
dexamethasone has approximately 20 times the anti-inflammatory
activity as prednisolone and 70 to 80
times that of hydrocortisone. Thymus involution studies show
dexamethasone possesses 25 times the
activity of prednisolone. In reference to mineralocorticoid activity,
dexamethasone does not cause
significant sodium or water retention. Metabolic balance studies show
that animals on controlled and
limited protein intake will exhibit nitrogen losses on exceedingly
high dosages.
INDICATIONS: Dexamethasone is indicated for the treatment of primary
bovine ketosis and as an anti-
inflammatory agent in the bovine and equine.
As supportive therapy, Dexamethasone may be