DERMASORB AF COMPLETE KIT clioquinol and hydrocortisone cream with hydrating gel

Страна: Соединенные Штаты

Язык: английский

Источник: NLM (National Library of Medicine)

Активный ингредиент:

HYDROCORTISONE (UNII: WI4X0X7BPJ) (HYDROCORTISONE - UNII:WI4X0X7BPJ)

Доступна с:

Crown Laboratories

ИНН (Международная Имя):

HYDROCORTISONE

состав:

HYDROCORTISONE 5 mg in 1 g

Тип рецепта:

PRESCRIPTION DRUG

Статус Авторизация:

unapproved drug other

Характеристики продукта

DERMASORB AF COMPLETE KIT- CLIOQUINOL AND HYDROCORTISONE CREAM WITH
HYDRATING GEL
CROWN LABORATORIES
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this labeling has not been_
_approved by FDA. For further information about unapproved drugs,
click here._
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DERMASORB AF COMPLETE KIT
DESCRIPTION
Iodochlorhydroxyquin (Clioquinol) is an antifungal agent and a member
of a family of drugs
called hydroxyquinolines. Chemically, Iodochlorhydroxyquin is
5-chloro-7-iodo-quinolin-8-ol. Its
structural formula is:
The topical corticosteroids constitute a class of primarily synthetic
steroids used as anti-inflammatory
and antipruritic agents. Hydrocortisone is a member of this class.
Chemically hydrocortisone is pregn-
4-ene-3,20-dione, 11, 17,21-trihydroxy, (11β)- Its structural formula
is:
Each gram of Dermasorb AF contains 5mg Hydrocortisone USP and 30mg
Iodochlorhydroxyquin USP
in a cream base consisting of water, cetyl alcohol, stearyl alcohol,
cetyl palmitate, sorbic acid, sodium
lauryl sulfate, glycerin, and polysorbate-80.
CLINICAL PHARMACOLOGY
Iodochlorhydroxyquin is a broad-spectrum antibacterial and antifungal.
Its precise mechanism of action
is unknown. Topical corticosteroids share anti-inflammatory,
antipruritic and vasoconstrictive actions.
The mechanism of anti-inflammatory activity of the topical
corticosteroids is unclear. Various
laboratory methods, including vasoconstrictor assays, are used to
compare and predict potencies and
some evidence suggests a recognizable correlation exists between
vasoconstrictor potency and
therapeutic efficacy in man.
PHARMACOKINETICS
The extent of percutaneous absorption of topical corticosteroids is
determined by many factors
including the vehicle, the integrity of the epidermal barrier, and the
use of occlusive dressings. Topical
corticosteroids can be absorbed from normal intact skin. Inflammation
and/or other disease processes in
the skin increase percutaneous absorption. Occlusive dressings
substantially increase the percutaneous
ab