Baytril 25 Flavour Antibacterial Oral Suspension

Страна: Новая Зеландия

Язык: английский

Источник: Ministry for Primary Industries

Активный ингредиент:

enrofloxacin

Доступна с:

Elanco New Zealand

ИНН (Международная Имя):

enrofloxacin

состав:

enrofloxacin 25 g/litre

Терапевтические области:

Antibiotic

Статус Авторизация:

ACVM Registered

Дата Авторизация:

2010-07-20

Характеристики продукта

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Issue Date: 14-10-2023
Page: 1 of 13
_The information above this line is not included in the label _
RESTRICTED VETERINARY MEDICINE
KEEP OUT OF REACH OF CHILDREN
FOR ANIMAL TREATMENT ONLY
BAYTRIL 25 FLAVOUR ANTIBACTERIAL ORAL SUSPENSION
DESCRIPTION:
Enrofloxacin is a synthetic drug from the class of the quinolone
carboxylic acid derivatives, also
known as fluoroquinolones. It has antibacterial activity against a
broad spectrum of gram negative and
gram positive bacteria, including Mycoplasma. (See Table 1). It is
rapidly absorbed from the digestive
tract, penetrating into all measured body tissues and fluids (See
Table 2).
Enrofloxacin has the chemical name
1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1, 4-dihydro-4-
oxo-3-quinolinecarboxylic acid.
MICROBIOLOGY:
Enrofloxacin exerts bactericidal activity by interaction with the A
subunit of DNA gyrase in the target
bacteria. The DNA gyrase is a topoisomerase which controls bacterial
replication, i.e., it catalyses
supercoiling by rewinding and rejoining of chromosomal DNA strands.
The fluoroquinolones also
possess activity against bacteria in the stationary phase by an
alteration of the permeability of the outer
membrane phospholipid layer of the cell wall. These mechanisms of
action explain the rapid loss of
viability of susceptible bacteria. With enrofloxacin, inhibitory and
bactericidal concentrations are
closely correlated. They are identical or differ in many cases within
one or two dilution steps at
maximum.
Enrofloxacin possesses antimicrobial activity at low concentration
against most gram negative bacteria,
many gram positive bacteria and against mycoplasmas. Enrofloxacin is
therefore active against the
micro-organisms that are primarily or secondarily involved in many of
the infectious diseases which
occur in small animals.
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Issue Date: 14-10-2023
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TABLE 1. Minimum Inhibitory Concentrations for enrofloxacin against
pathogens isolated from d