Страна: Малайзия
Язык: английский
Источник: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
OXYMETAZOLINE HYDROCHLORIDE
KOTRA PHARMA (M) SDN. BHD.
OXYMETAZOLINE HYDROCHLORIDE
10ml mL
KOTRA PHARMA (M) SDN. BHD.
AXCEL OXYMETAZOLINE 0.025% NASAL DROPS Oxymetazoline HCl (0.025% w/v) 1 _Consumer Medication Information Leaflet (RiMUP) _ WHAT IS IN THIS LEAFLET 1. What Axcel Oxymetazoline 0.025% Nasal Drops is used for. 2. How Axcel Oxymetazoline 0.025% Nasal Drops works. 3. Before you use Axcel Oxymetazoline 0.025% Nasal Drops. 4. How to take Axcel Oxymetazoline 0.025% Nasal Drops. 5. While you are using it. 6. Side effects. 7. Storage and disposal of Axcel Oxymetazoline 0.025% Nasal Drops. 8. Product description. 9. Manufacturer and Product Registration Holder. 10. Date of revision. WHAT AXCEL OXYMETAZOLINE 0.025% NASAL DROPS IS USED FOR Axcel Oxymetazoline 0.025% Nasal Drops is used for relief of nasal congestion in acute colds, paranasal sinusitis (inflammation of the sinuses at the air spaces within the bones of the face) and otitis media (inflammation of the middle ear). HOW AXCEL OXYMETAZOLINE 0.025% NASAL DROPS WORKS Oxymetazoline is a direct – acting sympathomimetic agent which has a vasoconstrictor effect on mucosal blood vessels. Sympathomimetic agent is widely used as nasal decongestants to provide symptomatic relief. They act by vasoconstriction and redistributing local blood flow to reduce oedema of the nasal mucosa (swelling of the mucous membrane) thus improving ventilation, drainage and nasal stuffiness. BEFORE YOU USE AXCEL OXYMETAZOLINE 0.025% NASAL DROPS _-When you must not use it _ Do not use Axcel Oxymetazoline 0.025% Nasal Drops if: If you are allergic or hypersensitive to Oxymetazoline and Benzalkonium Chloride. If you have inflammation of the skin and rhinitis sicca (chronic form of dryness of the mucous membranes). Do not use Axcel Oxymetazoline 0.025% Nasal Drops if you are pregnant, trying to get pregnant or think you may be pregnant. Do not use Axcel Oxymetazoline 0.025% Nasal Drops if you are breast-feeding. Ask your doctor or pharmacist for advice before taking any medicine. _-Before you start to use it _ Tell your doctor if: If you are receiving treatment with monoamine-ox Прочитать полный документ
MAL20040821AZ COMPOSITION: Contains Oxymetazoline HCl 0.025% w/v (Benzalkonium Cl 0.01% w/v as preservative) PRESENTATION: Clear, colourless liquid. INDICATIONS: Relief of nasal congestion in acute colds, paranasal sinusitis and otitis media. PHARMACOLOGY: _Mechanism of Action:_ Oxymetazoline is a direct-acting sympathomimetic agent which has a vasoconstrictor effect on mucosal blood vessels. Sympathomimetic agent mimic the actions produced by stimulation of postganglionic sympathetic or adrenergic nerves, including vasoconstriction of blood vessels supplying skin and mucous membranes. Topical use of Oxymetazoline has the advantage of selective of site of action and more rapid action than do oral agents. It acts within a few minutes and the effects last for up to 12 hours. Nasal congestion is frequently a symptom of conditions such as rhinitis. Sympathomimetic agents are widely employed as nasal decongestants to provide symptomatic relief. They act by vasoconstriction and redistributing local blood flow to reduce oedema of the nasal mucosa thus improving ventilation, drainage and nasal stuffiness. _Pharmacokinetics:_ Most sympathomimetic agents undergo enzymatic degradation in the gut and first-pass metabolism of the liver. They are inactivated by the enzymes catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO). The metabolites are excreted in the urine mainly as their glucuronide and ethereal sulphate conjugates. Oxymetazoline, however, is an imidazoline derivative and is more resistant to the inactivating enzymes of liver and other tissues. It is thus longer action and metabolised at a slower rate than the catecholamines such as ephedrine or phenylephrine. When used in the form of nasal drops it acts with a few minutes and the effects lasts for several hours. DIRECTION FOR USE: For nasal use. In cases of rhinitis and sinusitis small children receive 1 – 2 drops of the Axcel Oxymetazoline 0.025% Nasal Drops, instilled into each nostril, 2 – 3 times daily. Axcel Oxymetazoline 0.025% Nasal Drops sho Прочитать полный документ