Страна: Австралия
Язык: английский
Источник: Department of Health (Therapeutic Goods Administration)
lisinopril dihydrate
Fair-Med Healthcare Australia Pty Ltd
Lisinopril dihydrate
Registered
AURO-LISINOPRIL CONSUMER MEDICINE INFORMATION Version 2.5 _ _ Page 1 of 5 AURO-LISINOPRIL 5, 10 & 20 Lisinopril CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about AURO- LISINOPRIL. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking AURO- LISINOPRIL against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE . You may need to read it again. WHAT AURO-LISINOPRIL IS USED FOR AURO-LISINOPRIL lowers high blood pressure, called hypertension. It is also used to treat heart failure and patients who have just had a heart attack. Lisinopril belongs to a group of medicines called ACE inhibitors. HYPERTENSION: Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have hypertension (high blood pressure) when your blood pressure stays higher than is needed, even when you are calm and relaxed. There are usually no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems. You may feel fine and have no symptoms, but eventually hypertension can cause stroke, heart disease and kidney failure. AURO-LISINOPRIL helps to lower your blood pressure. HEART FAILURE: Heart failure means that the heart muscle cannot pump blood strongly enough to supply all the blood needed throughout the body. Heart failure is not the same as heart attack and does not mean that the heart stops working. Heart failure may start off with no symptoms, but as the condition progresses, patients may feel short of breath or may get tired easily after lig Прочитать полный документ
Product Information: AURO-LISINOPRIL 5, 10 and 20 (lisinopril 5mg, 10 mg and 20 mg tablets) Ver 3.4 Page 1 of 19 PRODUCT INFORMATION AURO-LISINOPRIL 5 (5 MG LISINOPRIL (AS DIHYDRATE) TABLETS) AURO-LISINOPRIL 10 (10 MG LISINOPRIL (AS DIHYDRATE) TABLETS) AURO-LISINOPRIL 20 (20 MG LISINOPRIL (AS DIHYDRATE) TABLETS) NAME OF THE MEDICINE The name of the medicine is Lisinopril as lisinopril dihydrate. CHEMICAL NAME: ( _S_ )-1-[ _N_ 2 -(1-carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate MOLECULAR FORMULA: C 21 H 31 N 3 O 5 · 2H 2 O. MOLECULAR WEIGHT: 441.53 CAS REGISTRY NUMBER: _83915-83-7_ DESCRIPTION Lisinopril dihydrate is white to off-white crystalline powder that is soluble in water, sparingly soluble in methanol and practically insoluble in ethanol. Lisinopril dihydrate is a synthetic peptide that is an oral, long acting angiotension converting enzyme inhibitor. It is a lysine analogue of enalaprilat (active metabolite of enalapril). AURO-LISINOPRIL is available as tablets containing 5 mg, 10 mg & 20 mg lisinopril as dihydrate. AURO-LISINOPRIL tablets contain following inactive ingredients: Calcium hydrogen phosphate anhydrous, mannitol, pregelatinised maize starch, magnesium stearate, iron oxide red CI77491 (AURO-LISINOPRIL 5 only) & iron oxide yellow CI77492 (AURO-LISINOPRIL 10 and 20). PHARMACOLOGY _MECHANISM OF ACTION _ Lisinopril is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin converting enzyme (ACE) that catalyses the conversion of Angiotensin I to the vasoconstrictor substance, Angiotensin II. Angiotensin II also stimulates aldosterone secretion by the adrenal cortex. Inhibition of ACE results in decreased concentrations of plasma angiotensin II which results in decreased vasopressor activity and decreased aldosterone secretion. The latter decrease may result in a small increase of serum potassium. In hypertensive patients with normal renal function treated with lisinopril alone for up to 24 weeks, the mean increase in serum potassium was approximately 0.1 mmol/L; however, approximatel Прочитать полный документ