Реагенты для иммуноферментного анализа: тесты иммунологические, предназначенные для использования на иммуноанализаторе NAISSA

Страна: Беларусь

Язык: русский

Источник: Министерством здравоохранения Республики (Центр экспертиз и испытаний в здравоохранении)

Доступна с:

NeoMedica d.o.o. Nis, РЕСПУБЛИКА СЕРБИЯ

класс:

изделия медицинского назначения

Производитель:

NeoMedica d.o.o. Nis

Дата Авторизация:

2022-11-02

Характеристики продукта

FOLATE
​
_Enzyme immunoassay for _
_quantitative determination of folate concentration_
_ _
PRODUCT NAME:
Cat.No. / REF
N1705M24FOL Folate
24 Tests
FOR IN VITRO DIAGNOSTIC USE ONLY
INTENDED USE
The test’s intended use is for quantitative determination
of folate concentration in the human serum.
INTRODUCTION
As one of the B vitamins, folate or vitamin B9 is included
in many functions in the body and its deficiency can
cause diseases in both the elderly and young children.
Folate
deficiency
is
associated
with
megaloblastic
anemia,
neural
tube
defects,
and
cardiovascular
diseases.
Folate plays an important role in brain development and
that
is why it
is necessary during growth.
The most
common defects caused by folate deficiencies are neural
tube defects.
Because of
the important
role in nucleic
acid synthesis, folate is useful in the form of supplements
during pregnancy and other cases of rapid tissue growth.
It
is also essential
in maintaining homocysteine balance
​​
which contributes as a factor in occurrence of occlusive
vascular disease and stroke. People susceptible to heart
disease and various forms of
cancer
can also benefit
from supplementation.
In the circulation,
folate is present
in several
different
forms, some of which are more stable than others. There
are
two
common
forms:
folic
acid
and
N-methyltetrahydrofolate,
the
latter
being
more
represented when it comes to analytical
methods due to
greater
stability.
Proteins that
bind it are responsible for
folate metabolism. There are two types in circulation: one
helps in binding to the cell
surface and the other soluble
form exists in the circulation.
These proteins,
too, have
the ability to bind several
different
derivatives
including
folic
acid
and
N-methyltetrahydrofolate.
Interaction
between folic acid and folate-binding protein is stronger
between
it
and
methyltetrahydrofolate.
Currently
available tests on the market
require an extraction step
to release the folate derivatives from the bond with the
folate-binding protein.
In the past,
folate