Țară: Australia
Limbă: engleză
Sursă: Department of Health (Therapeutic Goods Administration)
salbutamol sulfate
Amneal Pharma Australia Pty Ltd
salbutamol sulfate
Salbutamol AN CMI v4.0 Page 1 of 4 CONSUMER MEDICINE INFORMATION SALBUTAMOL AN Pronounced (sal-bew-tam-ol) _Contains the active ingredient salbutamol sulfate _ WHAT IS IN THIS LEAFLET? This leaflet answers some common questions about Salbutamol AN. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you taking Salbutamol AN against the benefits this medicine is expected to have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. This medicine is only part of a general plan to help you to manage your asthma or other chest conditions. You should discuss this plan with your doctor. Ask your doctor to check your treatment plan regularly. Keep this leaflet. You may need to read it again. WHAT SALBUTAMOL AN IS USED FOR The name of your medicine is Salbutamol AN. The medicine in your Salbutamol AN ampoules is delivered through a device called a nebuliser. Salbutamol belongs to a group of medicines called beta-2-agonists. These work rapidly to open up the air passages in your lungs. Salbutamol is inhaled into the lungs for the treatment of asthma. Asthma is a disease where the lining of the lungs become inflamed (red and swollen), making it difficult to breathe. This may be due to an allergy to house dust mites, smoke, air-borne pollution and other irritants. Salbutamol opens up the air passages in people suffering from asthma, bronchitis and other breathing problems. It may also be used before exercise to keep your air passages open if you start to wheeze or have difficulty breathing each time you exert yourself. Salbutamol may be used for the management of other conditions that are not mentioned above. Your doctor will be able to tell you about the specific condition for which you have been prescribed salbutamol. This medicine is available only with a doctor's prescription. BEFORE YOU USE SALBUTAMOL AN _WHEN YOU MUST NOT BE _ _GIVEN IT_ D Citiți documentul complet
Salbutamol AN PI V1.0 1/7 PRODUCT INFORMATION SALBUTAMOL AN NAME OF THE MEDICINE Active: Salbutamol Sulfate BP. Chemical name: di[(RS)-2-(1,1-dimethylethyl)amino-1-(4-hydroxy-3- hydroxymethylphenyl)ethanol]sulfate Molecular formula: (C 13 H 21 NO 3 ) 2 , H 2 SO 4 CAS number: 51022-70-9 MW: 576.7 DESCRIPTION Salbutamol sulfate is a white or almost white, crystalline, odourless powder with a slightly bitter taste. It is freely soluble in water, slightly soluble in alcohol, chloroform and ether, very slightly soluble in methylene chloride. Salbutamol sulfate 1.2 mg is approximately equivalent to salbutamol 1 mg. Inactive ingredients: Sodium chloride, sulfuric acid (for pH adjustment), water for injection. PHARMACOLOGY _Action: _Selective _β_ _2 _ adrenoceptor agonist Salbutamol is a long acting, relatively selective _ β_ _2_ _-_receptor stimulant. Administration by inhalation results in direct stimulation of _β_ _2_ _-_receptors in bronchial smooth muscle and hence bronchodilation. This is thought to be due to stimulation of adenyl cyclase by salbutamol, resulting in increased levels of cyclic AMP within cells. These are thought to inhibit the entry of calcium ions into the cells, thus inhibiting smooth muscle contraction. High levels of cyclic AMP in mast cells may also inhibit the release of histamine and slow reacting substance-A (SRS-A). After administration of salbutamol stimulation of both _ β_ _1 _ and_ β_ _2 _ receptors occurs because _ β_ _2 _ selectivity is not absolute. This results in the _ β_ _1 _ effect of cardiac stimulation, though not so much as with isoprenaline, and _ β_ _2 _ effects of peripheral vasodilation and hypotension, skeletal muscle tremor and uterine muscle relaxation. Stimulation of _β_ _2 _ receptors can result in changes in serum levels of glucose, insulin and potassium. _Pharmacokinetics: _ _Absorption: _Following inhalation of salbutamol the onset of action is 5 to 15 minutes. Only 10 to 20% of the dose reaches the lungs, the remainder stays in the mouth, stomach or on the Citiți documentul complet