Țară: Australia
Limbă: engleză
Sursă: Department of Health (Therapeutic Goods Administration)
Dipyridamole
Boehringer Ingelheim Pty Ltd
Medicine Registered
CMI0020-05 1 PERSANTIN® AMPOULE 10MG/2ML _Dipyridamole _ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Persantin Ampoule. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have benefits and risks. Your doctor has weighed the risks of you using Persantin against the benefits they expect it will have for you. ASK YOUR DOCTOR OR PHARMACIST IF YOU HAVE ANY QUESTIONS ABOUT YOUR MEDICINE OR IF YOU HAVE ANY CONCERNS ABOUT BEING TREATED WITH PERSANTIN. This leaflet was last updated on the date at the end of this leaflet. More recent information may be available. The latest Consumer Medicine Information is available from your pharmacist, doctor, or from www.medicines.org.au [http://www.medicines.org.au/]and may contain important information about the medicine and its use of which you should be aware. KEEP THIS LEAFLET. You may need to read it again later. WHAT PERSANTIN AMPOULE IS USED FOR Persantin is a heart medicine. It is used as a tool in detecting potential problems on how the heart functions in times of stress. It is therefore useful in predicting the likelihood of the risks of heart disease. Persantin increases blood flow to the heart by causing the blood-supplying arteries to widen. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE IS BEING GIVEN TO YOU. Your doctor may have prescribed it for another reason. BEFORE YOU ARE GIVEN PERSANTIN AMPOULE _WHEN YOU SHOULD NOT BE _ _GIVEN IT _ YOU SHOULD NOT BE GIVEN PERSANTIN IF YOU HAVE AN ALLERGY TO: any medicine containing dipyridamole any of the ingredients listed at the end of this leaflet. Citiți documentul complet
PI0090-05 1 PERSANTIN (DIPYRIDAMOLE) NAME OF THE MEDICINE Approved Name: Dipyridamole Chemical Name: 2,6-bis(diethanolamino)-4,8-dipiperidino-pyrimido[5,4-d]pyrimidine CAS No: 58-32-2 Laboratory Code: R-A 8-BS Molecular Formula: C 24 H 40 N 8 O 4 Molecular Weight: 504.6 Structural Formula: DESCRIPTION Dipyridamole is an odourless, yellow crystalline powder with a bitter taste. It has a melting point in the range of 164-168 C, and is soluble in dilute acids, methanol, ethanol and chloroform. PERSANTIN Ampoules contain dipyridamole 10 mg in 2 mL and are intended for intravenous administration. The inactive ingredients are: tartaric acid, macrogol 600, hydrochloric acid (to adjust pH) and purified water. PHARMACOLOGY Dipyridamole is a coronary vasodilator. It produces vasodilation indirectly via two mechanisms, namely the inhibition of adenosine uptake which leads to an increase in the circulating adenosine, and the inhibition of cGMP-phosphodiesterase. PI0090-05 2 Vasodilation induced by intravenous PERSANTIN leads to regional redistribution of coronary blood flow and may lead to abnormalities in the distribution of imaging agent and ventricular function in patients with coronary artery disease. The normal vessels dilate with enhanced flow, leaving relatively reduced pressure and flow across areas of haemodynamically important coronary stenoses. Dipyridamole also has an antithrombotic action. PHARMACOKINETICS (Most pharmacokinetic data refer to healthy volunteers.) Adequate curve fitting is achieved by a 3 compartment model: (a) A rapid alpha phase, with a half-life of about 3 minutes, presumably Citiți documentul complet