Țară: Statele Unite ale Americii
Limbă: engleză
Sursă: NLM (National Library of Medicine)
NITROGLYCERIN (UNII: G59M7S0WS3) (NITROGLYCERIN - UNII:G59M7S0WS3)
Rebel Distributors Corp
NITROGLYCERIN
NITROGLYCERIN 0.4 mg
ORAL
PRESCRIPTION DRUG
Nitroglycerin is indicated for the acute relief of an attack or prophylaxis of angina pectoris due to coronary artery disease. Sublingual nitroglycerin therapy is contraindicated in patients with early myocardial infarction, severe anemia, increased intracranial pressure and those with a known hypersensitivity to nitroglycerin. Administration of Nitroglycerin tablets USP is contraindicated in patients who are using Viagra® (sildenafil citrate). Viagra® has been shown to potentiate the hypotensive effects of organic nitrates.
Nitroglycerin Tablets, USP are supplied as follows: 0.4 mg - White tablet embossed with a "4". 4 x Bottles of 25: NDC 21695-697-25 Bottle of 100: NDC 21695-810-00
unapproved drug other
NITROGLYCERIN- NITROGLYCERIN TABLET REBEL DISTRIBUTORS CORP _Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been_ _approved by FDA. For further information about unapproved drugs, click here._ ---------- NITROGLYCERIN TABLETS, USP RX ONLY DESCRIPTION Nitroglycerin, an organic nitrate, is a vasodilating agent. The chemical name for nitroglycerin is 1,2,3- propanetriol trinitrate. The chemical structure is: Nitroglycerin tablets USP are compressed sublingual nitroglycerin tablets containing the non-volatile nitroglycerin fixing agent polyethylene glycol. The tablets contain 0.3 mg (1/200 grain), 0.4 mg (1/150 grain), and 0.6 mg (1/100 grain) nitroglycerin. Also contains lactose NF, polyethylene glycol 3350 NF, microcrystalline cellulose NF, colloidal silicon dioxide NF, and magnesium stearate NF. CLINICAL PHARMACOLOGY Relaxation of vascular smooth muscle is the principal pharmacologic action of nitroglycerin. The mechanism by which nitroglycerin produces relaxation of smooth muscle is unknown. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds. Dilation of the postcapillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, reducing left ventricular end-diastolic pressure (preload). Arteriolar relaxation reduces systemic vascular resistance and arterial pressure (afterload). Myocardial oxygen consumption or demand (as measured by the pressure-rate product, tension-time index and stroke-work index) is decreased by both the arterial and venous effects of nitroglycerin, and amore favorable supply-demand ratio can be achieved. Nitroglycerin also dilates large epicardial coronary arteries; however, the extent to which this effect contributes to the relief of exertional angina is unclear. Therapeutic doses of nitroglycerin may reduce systolic, diastolic, and mean arterial blood pressure. Effective coronary perfusion pressure is usual Citiți documentul complet