Țară: Malaezia
Limbă: engleză
Sursă: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
INDOMETHACIN
Y.S.P. INDUSTRIES (M) SDN BHD
INDOMETHACIN
1500 Capsule Capsules; 1000 Capsule Capsules; 10 x 10 Units; 10 x 50 Units
Y.S.P. INDUSTRIES (M) SDN BHD
_Consumer Medication Information Leaflet (RiMUP)_ 1 | INDOMEN CAPSULE Indomethacin (25mg) WHAT IS IN THIS LEAFLET 1. What INDOMEN CAPSULE is used for 2. How INDOMEN CAPSULE works 3. Before you use INDOMEN CAPSULE 4. How to use INDOMEN CAPSULE 5. While you are using INDOMEN CAPSULE 6. Side effects 7. Storage and disposal of INDOMEN CAPSULE 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT INDOMEN CAPSULE IS USED FOR INDOMEN CAPSULE is used for arthritis, rheumatism, arthritis deforman (inflammation joint disease) , and other inflammatory conditions. HOW INDOMEN CAPSULE WORKS INDOMEN CAPSULE consists of active ingredient Indomethacin. Indomethacin belongs to the group of medicine called Non- Steroidal Anti- inflammatory Drug (NSAIDs) which works by relief of pain, and reduction of fever and swelling. BEFORE YOU USE INDOMEN CAPSULE _-When you must not use it _ Do not use INDOMEN CAPSULE: If you are hypersensitivity to Indomethacin or other ingredients listed at the end of this leaflet. Symptoms of allergic might include asthma, runny nose, skin rash, and face swelling. If you think you may be allergic, ask your doctor for advice. _Pregnancy and lactation _ Please consult your doctor before start to use INDOMEN CAPSULE if you are pregnant, plan to become pregnant, breast-feeding or intend to breast-feed. Your doctor will have weighed the risks of you taking INDOMEN CAPSULE against the benefits they expect it will have for you. _-Before you start to use it _ Tell your doctor if you have or have had: - Hypersensitive to, or have had an allergic reaction to aspirin or other NSAIDs. - kidney problem; - bleeding disorders; - seizure; - Parkinson disease; - psychiactric disorder; - heart disease or stroke; - high blood pressure; - fluid retention; - ulcer, bleeding or perforation of the stomach or intestinal. Indomethacin may cause severe skin reactions, e.g. exfoliative dermatitis, toxic epidermal necrolysis, Steven- Johnson Syndrome. Symptoms may include skin rash, blisters Citiți documentul complet
_J INDOMEN CAPSULE LNGREDIENT(S): Each capsule contains: lndomethacin .................................................................................................................................... 25mg PHARMACODYNAMICS: 1. lndomethacin is a potent inhibitor of prostaglandin synthesis in vitro. Concentrations are reached during therapy which have been demonstrated to have an effect in vivo as well.Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin, inducing pain in animal models. Moreover, prostaglandins are known to be among the mediators of inflammation. Since lndomethacin is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues. 2. lndomethacin has been shown to be an effective anti-inflammatory agent, appropriate for long term use in rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. 3. lndomethacin suppresses inflammation in rheumatoid arthritis as demonstrated by relief of pain, and reduction of fever, swelling and tenderness. Improvement in patients treated with lndomethacin for rheumatoid arthritis has been demonstrated by a reduction in joint swelling, average number of joints involved, and morning stiffness; by increasing mobility as demonstrated by a decrease in walking lime; and by improving functional capability as demonstrated by an increase in grip strength. PHARMACOKINETICS: lndomethacin is readily absorbed from the gastrointestinal tract with peak plasma concentrations being reached about 2 hours after a dose. II has a half-life of about 4.5 hours and about 99 % is bound to plasma proteins. II is metabolized and undergoes enterohepatic circulation. Excretion of lndomethacin and metabolites as glucuronide conjugates, are predominantly in the urine with lesser amount appearing in the feces. LNDICATION(S): Arthritis, Rheumatism, Arthritis deformans, and other inflammatory conditions. DOSAGE AND ADMINISTRATION: Usual adult dose is 1 capsule 1 - 3 times daily. The initial dose is 1 Citiți documentul complet