hovid-Folic Acid Tablet 5mg

Țară: Malaezia

Limbă: engleză

Sursă: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredient activ:

Folic Acid

Disponibil de la:

HOVID BERHAD

INN (nume internaţional):

Folic Acid

Unități în pachet:

100Tablet Tablets

Produs de:

HOVID BERHAD

Caracteristicilor produsului

DESCRIPTION
Round, yellow uncoated tablet, bevel-edged, flat-faces, "HD"
and break-bar embossed on one face.
COMPOSITION
Each tablet contains: Folic Acid 5 mg.
PHARMACODYNAMICS
Folic acid is a member of the vitamin-B group. It is reduced
in the body to tetrahydrofolate, which is a coenzyme for
various
metabolic
processes
including
the
synthesis
of
purine and pyrimidine nucleotides, including the synthesis of
DNA; it is also involved in some amino-acid conversion and
in the formation and utilization of formate.
Folic acid is necessary for normal erthropoiesis, including
maturation
of
megaloblasts
into
normoblasts
and
nucleoprotein synthesis.
PHARMACOKINETICS
ABSORPTION: Commercially available folic acid is almost
completely absorbed from the gastrointestinal tract, even in
the
presence
of
malabsorption
due
to
tropical
sprue,
although food folates are not.
BLOOD CONCENTRATION: Physiological blood concentrations
are about 350 ng/ml
HALF-LIFE: Biological half-life, about 0.7 hours.
DISTRIBUTION: Widely and rapidly distributed throughout the
body and large amounts are stored in the liver, mainly as
methylated folates; normal body stores are of the order 5 to
10mg, 50% of which is found in the liver.
PROTEIN BINDING: About 66% bound to plasma proteins.
METABOLIC
REACTIONS:
Folic
acid
is
converted
to
its
metabolically active form (tetrahydrofolic acid) by hepatic
dihydrofolate reductase in the liver.
EXCRETION: 20 to 90% of an ingested dose is excreted in the
urine
in
24
hours;
the
percentage
of
a
dose
excreted
appears to be dose-dependent as after a 5mg - dose 50% is
excreted in 24 hours and after a 15mg dose about 90% is
excreted in 24 hours. It is excreted almost all as metabolites,
however, if beyond excess daily needs, it is mainly in the
unchanged form.
INDICATIONS
For the prevention and treatment of folate deficiency states.
For the prevention of neural tube defect in the foetus.
CONTRAINDICATIONS
Folic
acid
should
never
be
given
in
the
treatment
of
pernicious anaemia.
PRECAUTIONS
•
Large and continuous doses o