hovid-Celecoxib Capsule 200mg

Țară: Malaezia

Limbă: engleză

Sursă: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredient activ:

CELECOXIB

Disponibil de la:

HOVID BERHAD

INN (nume internaţional):

CELECOXIB

Unități în pachet:

100 Capsules; 30 Capsules; 10 Capsules

Produs de:

HOVID BERHAD

Prospect

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
HOVID-CELECOXIB CAPSULE 200 MG
Celecoxib (200 mg)
1
WHAT IS IN THIS LEAFLET
1.
What hovid-Celecoxib Capsule 200
mg is used for
2.
How hovid-Celecoxib Capsule 200
mg works
3.
Before
you
use
hovid-Celecoxib
Capsule 200 mg
4.
How
to
use
hovid-Celecoxib
Capsule 200 mg
5.
While
you
are
using
hovid-
Celecoxib Capsule 200 mg
6.
Side effects
7.
Storage
and
Disposal
of
hovid-
Celecoxib Capsule 200 mg
8.
Product description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT
HOVID-CELECOXIB
CAPSULE
200
MG IS USED FOR

For the management of acute pain in
adults and for the treatment of primary
dysmenorrhoea.

Relief of the acute and chronic pain
and
inflammation
of
rheumatoid
arthritis and osteoarthritis.

Relief
of
signs
and
symptoms
of
ankylosing spondylitis.

For relief of low back pain.
HOW HOVID-CELECOXIB CAPSULE 200 MG
WORKS
Celecoxib
is
a
nonsteroidal
anti-
inflammatory drug (NSAID). It works
by
reducing
hormones
that
cause
inflammation and pain in the body.
BEFORE
YOU
USE
HOVID-CELECOXIB
CAPSULE 200 MG
_- When you must not use it _
_ _
Do not take this medicine if:

You are allergic to celecoxib or any of
the other ingredients of this medicine.

You have had an allergic reaction to a
group
of
medicines
called
“sulfonamides” (e.g. some antibiotics
used to treat infections)

You currently have an ulcer in your
stomach or intestines, or bleeding in
your stomach or intestines.

As a result of taking acetylsalicylic
acid or any other anti-inflammatory
and pain-relieving medicine (NSAID)
you
have
had
asthma,
nose
polyps,
severe nose congestion, or an allergic
reaction such as an itchy skin rash,
swelling of the face, lips, tongue or
throat,
breathing
difficulties
or
wheezing.

You are pregnant. If you can become
pregnant
during
ongoing
treatment
you
should
discuss
methods
of
contraception with your doctor.

You are breast-feeding

You have severe liver disease

You have severe kidney disease.

You have an in

Caracteristicilor produsului

HOVID-CELECOXIB CAPSULE 200 MG
VICELxx-0 (MY)3
DESCRIPTION
White opaque/white opaque capsule with “CL200” printed on one end
and
“hovid” printed on the other end
Fill material: white to off white granules
Capsule size: size 0
COMPOSITION
Each capsule contains Celecoxib 200 mg.
PHARMACODYNAMICS
MECHANISM OF ACTION: Celecoxib is an oral, selective, cyclooxygenase-2
(COX-2) inhibitor within the clinical dose range (200-400 mg daily).
No
statistically significant inhibition of COX-1 (assessed as _ex vivo_
inhibition of
thromboxane B2 [TxB2] formation) was observed in this dose range in
healthy volunteers.
PHARMACODYNAMIC EFFECTS: Cyclooxygenase is responsible for generation
of prostagladins. Two isoforms, COX-1 and COX-2, have been identified.
COX-2 is the isoform of the enzyme that has been shown to be induced
by
pro-inflammatory stimuli and has been postulated to be primarily
responsible
for the synthesis of prostanoid mediators of pain, inflammation, and
fever.
COX-2 is also involved in ovulation, implantation and closure of the
ductus
arteriosus, regulation of renal function, and central nervous system
functions
(fever induction, pain perception and cognitive function). It may also
play a
role in ulcer healing. COX-2 has been identified in tissue around
gastric
ulcers in human but its relevance to ulcer healing has not been
established.
The difference in antiplatelet activity between some COX-1 inhibiting
NSAIDs and COX-2 selective inhibitors may be of clinical significance
in
patients at risk of thrombo-embolic reactions. COX-2 selective
inhibitors
reduce the formation of systemic (and therefore possibly endothelial)
prostacyclin without affecting platelet thromboxane.
Celecoxib is a diaryl-substituted pyrazole, chemically similar to
other
non-arylamine sulfonamides (e.g. thiazides, furosemide) but differs
from
arylamine
sulfonamides
(e.g.
sulfamethoxizole
and
other
sulfonamide
antibiotics).
A dose dependent effect on TxB2 formation has been observed after high
doses of celecoxib. However, in healthy sub