EPINEPHRINE INJECTION SOLUTION

Țară: Canada

Limbă: engleză

Sursă: Health Canada

Ingredient activ:

EPINEPHRINE (EPINEPHRINE BITARTRATE)

Disponibil de la:

LABORATOIRE AGUETTANT

Codul ATC:

C01CA24

INN (nume internaţional):

EPINEPHRINE

Dozare:

1MG

Forma farmaceutică:

SOLUTION

Compoziție:

EPINEPHRINE (EPINEPHRINE BITARTRATE) 1MG

Calea de administrare:

INTRAVENOUS

Unități în pachet:

15G/50G

Tip de prescriptie medicala:

Ethical

Zonă Terapeutică:

ALPHA-AND BETA-ADRENERGIC AGONISTS

Rezumat produs:

Active ingredient group (AIG) number: 0104871003; AHFS:

Statutul autorizaţiei:

APPROVED

Data de autorizare:

2021-10-07

Caracteristicilor produsului

PRESCRIBING INFORMATION
EPINEPHRINE INJECTION
0.1 mg / mL (Single-Use Syringes)
Sterile Solution
House standard
(Sympathomimetic)
Laboratoire Aguettant
1 rue Alexander Fleming
69007 Lyon
France
Imported to Canada by:
Aguettant Canada Inc.
1470 Peel Suite A-152, Montreal QC, H3A 1T1
Date of preparation:
07-10-2021
Control No.: 235107
2
NAME OF DRUG
EPINEPHRINE INJECTION
House Standard
0.1 mg / mL (Single-Use Syringes)
Sterile Solution
THERAPEUTIC CLASSIFICATION
Sympathomimetic
Epinephrine Injection is a parenteral adrenergic (sympathomimetic)
agent and cardiac stimulant.
ACTION AND CLINICAL PHARMACOLOGY
The actions of epinephrine resemble the effects of stimulation of
adrenergic nerves. It acts on both
alpha and beta receptor sites of sympathetic effector cells. Its most
prominent actions are on the beta
receptors of the heart, vascular and other smooth muscle. When given
by rapid intravenous injection,
it
produces
a
rapid
rise
in
blood
pressure,
mainly
systolic,
by
(1)
direct stimulation of cardiac
muscle which increases the strength of ventricular contraction, (2)
increasing the heart rate and (3)
constriction of the arterioles in the skin, mucosa and splanchnic
areas of the circulation.
When
given
by
slow
intravenous
injection,
epinephrine
usually
produces
only
a
moderate
rise in
systolic and a fall in diastolic pressure. Although some increase in
pulse pressure occurs, there is
usually
no
great
elevation
in
mean
blood
pressure.
Accordingly,
the
compensatory
reflex
mechanisms that come into play with a pronounced increase in blood
pressure do not antagonize the
direct cardiac actions of epinephrine as much as with catecholamines
that have a predominant action
on alpha receptors.
Total
peripheral
resistance
decreases by
action
of epinephrine
on
beta
receptors
of
the
skeletal
muscle vasculature and blood flow is thereby enhanced. Usually this
vasodilator effect of the drug
on
the
circulation
predominates
so
that
the
modest
rise
in
systolic
pressure
which
follows slow
injection
or
absorption
is
mainly
the
result
o