EDTA INJECTION 150MGML (VIAL)

Țară: Malaezia

Limbă: engleză

Sursă: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredient activ:

DISODIUM EDETATE

Disponibil de la:

DUOPHARMA (M) SDN. BHD.

INN (nume internaţional):

DISODIUM EDETATE

Unități în pachet:

20ml mL; 25Units Units

Produs de:

DUOPHARMA (M) SDN. BHD.

Caracteristicilor produsului

[DUOPHARMA (M) SDN BHD]
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[REVISION DATE: 26.09.2019]
EDTA INJECTION 150MG/ML (VIAL)
DESCRIPTION: EDTA INJECTION 150 MG/ML (VIAL): A clear, aqueous,
colourlesss sterile solution.
COMPOSITION: Each ml contains Edetate Disodium Hydrous 166 mg
(equivalent to 150 mg Edetate Disodium Anhydrous USP).
PHARMACODYNAMICS: Edetate Disodium forms chelates with the cations of
the calcium and many divalent and trivalent metals. Because of its
affinity for calcium, edetate
disodium will produce a lowering of the serum calcium level during
intravenous infusion.
_HYPERCALCEMIA _– Edetate Disodium forms soluble complexes with
calcium in the blood, which are filtered by the glomeruli and not
reabsorbed by the renal tubules. Chelation with
calcium produces a lowering of serum concentrations and a mobilization
of extracirculatory calcium stores, especially from bone, during slow
intravenous infusion. Theoretically, 1
gram of edetate disodium will chelate 120 mg of calcium. Hypocalcemic
tetany, seizures, severe cardiac arrhythmias, and respiratory arrest
may occur with the rapid decrease in
serum calcium concentration. However, the mobilization of calcium from
bone may lessen the risk of hypocalcemia. Calcium ion concentrations
in cerebrospinal fluid are not
affected by edetate disodium.
_DIGITALIS TOXICITY _– Edetate disodium exerts a negative inotropic
effect on the heart. The chronotopic and inotropic effects of
digitalis glycosides on the ventricles of the heart are
transiently antagonized by the hypocalcemia induced by edetate
disodium.
Edetate disodium also forms chelates with and increases urinary
excretion of other polyvalent metals, such as magnesium, zinc, and
other trace elements.
Although edetate disodium does not form a chelate with potassium, the
serum concentration of potassium may be decreased and the urinary
excretion of potassium increased.
PHARMACOKINETICS: Rapidly excreted by kidneys, principally as the
calcium chelate; 95% of a dose appears in the urine within 24 hours;
changes in the urine flow and