EBERIL 30mg Tablet

Țară: Malaezia

Limbă: engleză

Sursă: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredient activ:

ETORICOXIB

Disponibil de la:

MEDISPEC (M) SDN.BHD

INN (nume internaţional):

ETORICOXIB

Unități în pachet:

3x10 Tablets; 10 x 10 Tablets

Produs de:

UNISON LABORATORIES CO.LTD

Prospect

_ _
_ _
_ _
_ _
_ _
_ _
_ _
_ _
_ _
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _
EBERIL 30MG/60MG/90MG/120MG TABLET
Etoricoxib (30mg, 60 mg, 90 mg and 120 mg) 1
WHAT IS IN THIS LEAFLET
1.
What Eberil is used for
2.
How Eberil works
3.
Before you take Eberil
4.
How to take Eberil
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of Eberil
8.
Product Description
9.
Manufacturer
and
Product
Registration Holder
10.
Date of revision
WHAT EBERIL IS USED FOR
YOUR
DOCTOR
HAS
PRESCRIBED
EBERIL
TABLET FOR:
•
Treatment of osteoarthritis
•
Treatment of rheumatoid arthritis
•
Treatment of ankylosing spondylitis
•
Treatment of acute pain after minor
dental procedures
•
Treatment of menstrual pain
•
Treatment of gout attacks
Osteoarthritis is a joint disease. It results
from
the
gradual
breakdown
of
the
cartilage that cushions the ends of the
bones, resulting in pain, inflammation,
tenderness,
stiffness,
and
physical
disability.
Rheumatoid arthritis is a chronic disease
that causes pain, stiffness, swelling and
loss
of
function
in
the
joints
and
inflammation in other body organs.
Ankylosing
spondylitis
is
an
inflammatory disease of the spine and
large joints.
Gout
is
a
disorder
characterized
by
sudden, recurring attacks of pain and
inflammation in one or more joints.
HOW EBERIL WORKS
Eberil tablet is a member of a group of
medicines
called
selective
COX-2
inhibitors that are used to reduce pain
and inflammation. Eberil tablet is not a
narcotic.
BEFORE YOU TAKE EBERIL
_- When you must not use it _
Do not take Eberil if you:
•
are allergic to any of its ingredients
•
have heart failure, a heart attack,
bypass surgery, chest pain, narrow
or
blocked
arteries
of
the
extremities, a stroke or mini stroke
•
have high blood pressure that has
not been controlled by treatment
_- Before you start to use it _
Tell
your
doctor
about
any
medical
problems or allergies you have now or
have had, including:
•
History of angina, heart attack or a
blocked artery in your heart
•
Narrow
or
blocked
arteries

Caracteristicilor produsului

1 of 4
EBERIL 30
EBERIL 60
EBERIL 90
EBERIL 120
Each film coated tablet contains:
ETORICOXIB 30 MG
ETORICOXIB 60 MG
ETORICOXIB 90 MG
ETORICOXIB 120 MG
PRODUCT DESCRIPTION:
_30 MG: _Light green, apple-shaped, biconvex, film coated tablet with
engraved 30 on one side and plain on the other side
_60 MG: _Green, apple-shaped, biconvex, film coated tablet with
engraved 60 on one side and plain on the other side
_90 MG: _White, apple-shaped, biconvex, film coated tablet with
engraved 90 on one side and scored on the other side
_120 MG: _Pale-green, apple-shaped, biconvex, film coated tablet with
engraved 120 on one side and scored on the other side
MECHANISM OF ACTION:
_PHARMACOLOGY _
Etoricoxib is a non-steroidal anti-inflammatory drug (NSAID) that
exhibits anti-inflammatory, analgesic, and antipyretic activities in
animal models. Etoricoxib is a potent, orally active,
highly selective cyclooxygenase-2 (COX-2) inhibitor within and above
the clinical dose range. Two isoforms of cyclo-oxygenase have been
identified: cyclooxygenase-1 (COX-1) and
cyclooxygenase-2 (COX-2). COX-1 is responsible for
prostaglandin-mediated normal physiologic functions such as gastric
cytoprotection and platelet aggregation. Inhibition of COX-1
by nonselective NSAIDs has been associated with gastric damage and
platelet inhibition. COX-2 has been shown to be primarily responsible
for the synthesis of prostanoid mediators of
pain, inflammation, and fever. Selective inhibition of COX-2 by
Etoricoxib decreases these clinical signs and symptoms with decreased
GI toxicity and without effects on platelet
function.
Etoricoxib produces dose-dependent inhibition of COX-2 without
inhibition of COX-1 at doses up to 150 mg daily.
Platelet Function
Multiple doses of Etoricoxib up to 150 mg administered daily up to
nine days have no effect on bleeding time. There is no inhibition of
_ex vivo_ arachidonic acid- or collagen-induced
platelet aggregation at steady state with doses of Etoricoxib up to
150 mg. These findings are consistent with the COX-2 selectivi