Țară: Australia
Limbă: engleză
Sursă: Department of Health (Therapeutic Goods Administration)
Carbetocin
Ferring Pharmaceuticals Pty Ltd
Medicine Registered
DURATOCIN ® INJECTION _Carbetocin_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Duratocin. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you having Duratocin against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR. KEEP THIS LEAFLET. You may need to read it again. WHAT DURATOCIN IS USED FOR Duratocin contains carbetocin, a substance which is an oxytocic agent and causes the womb (uterus) to contract. Duratocin is used to minimise post delivery bleeding in women who have delivered their baby by elective caesarean section under local anaesthetic around the spinal cord (epidural). _HOW IT WORKS_ In some women, following delivery by caesarean section, the womb fails to contract quickly enough which increases the risk of bleeding. Drugs that act directly on the womb to make it contract are used to minimise post delivery bleeding and are sometimes called oxytocic agents because they act in a similar manner to oxytocin. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY THIS MEDICINE HAS BEEN PRESCRIBED FOR YOU. Your doctor may have prescribed it for another reason. Duratocin is available only with a doctor's prescription. It is not addictive. BEFORE YOU ARE GIVEN DURATOCIN _WHEN YOU MUST NOT BE GIVEN_ _IT_ DURATOCIN MUST NOT BE GIVEN IF YOU HAVE AN ALLERGY TO: • carbetocin, the active ingredient, or to any of the ingredients listed at the end of this leaflet • any medicines containing oxytocin. Symptoms of an allergic reaction may include: • shortness of breath • wheezing or difficulty breathing • swelling of the face, lips, tongue or other parts of the body • rash, itching or hives on the skin. YOU MUST NOT BE GIVEN DURATOCIN DURING PREGNANCY OR ANY TIME BEFORE DELIVERY OF THE BABY. YOU MUST NOT BE GIVEN DURATOCIN IF Citiți documentul complet
PRODUCT INFORMATION #15449-v8A DURATOCIN (CARBETOCIN INJECTION) NAME OF THE DRUG Carbetocin SYNONYMS: 2,1-Desamino-4, 1-desthio-O4, 2-Methyl 1 [1-homocysteine] oxytocin 1-desamino-1-monocarba-2-(0-methyl)-tyrosine-oxytocin (2-0-methyltyrosine)-1-deaminocarba-1-oxytocin (6,1- deaminocystathionine, 2-0-methyl-tyrosine)-oxytocin [Tyr(Me) 2 ]-desamino-1-carba-oxytocin CAS: 37025-55-1 STRUCTURE: O C Tyr Ile Glu Asp Cys Pro Leu Gly NH 2 Me NH 2 NH 2 CH 2 CH 2 CH 2 MOLECULAR FORMULA: C 45 H 69 N 11 O 12 S MOLECULAR WEIGHT: 988.1 DESCRIPTION Carbetocin is a white, fluffy lyophilized powder, soluble in water, ethanol, methanol and acetic acid. Carbetocin is insoluble in ether and petroleum ether. Each ampoule contains 100μg of carbetocin, 9 mg sodium chloride, acetic acid – glacial to pH 3.8 and water for injections to 1 mL. PHARMACOLOGY DURATOCIN (carbetocin injection) is a long-acting synthetic octapeptide analogue of oxytocin with agonist properties. It can be administered intravenously as a single dose immediately following delivery by caesarean section under epidural or spinal anaesthesia, to prevent uterine atony and postpartum haemorrhage. The clinical and pharmacological properties of carbetocin are similar to those of naturally occurring oxytocin, another posterior pituitary hormone. In in vitro studies, carbetocin was shown to bind to the oxytocin receptor with similar affinity as the natural peptide. Carbetocin elicited similar uteronic and galactogogic effects to oxytocin in animals and in vitro. Carbetocin was less potent than oxytocin, but its action was more prolonged. Citiți documentul complet