Bisloc 2.5mg Tablet

Țară: Malaezia

Limbă: engleză

Sursă: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredient activ:

BISOPROLOL FUMARATE

Disponibil de la:

MEDISPEC (M) SDN.BHD

INN (nume internaţional):

BISOPROLOL FUMARATE

Unități în pachet:

100tablet Tablets

Produs de:

UNISON LABORATORIES CO.LTD

Caracteristicilor produsului

1
BISLOC TABLET PACKAGE INSERT
BRAND OR PRODUCT NAME _ _
Bisloc 2.5mg Tablet
Bisloc 5mg Tablet
NAME AND STRENGTH OF ACTIVE SUBSTANCE(S)
Bisoprolol fumarate 2.5
mg equivalent to bisoprolol 2.5mg
Bisoprolol fumarate 5mg equivalent to bisoprolol 5mg
PRODUCT DESCRIPTION
Bisloc 25mg Tablet
White, heart-shaped, biconvex, film coated tablet with scored on one
side and plain on the other
Bisloc 5mg Tablet
Light yellow, heart-shaped, biconvex, film coated tablet with scored
on one side and plain on the
other.
PHARMACODYNAMICS
Bisoprolol fumarate, a cardioselective inhibitor of
beta(1)-adrenoceptor, has no significant
intrinsic sympathomimetic activity or membrane stabilizing activity in
its therapeutic dosage. It
also exhibits beta(2)-adrenoceptors inhibition and negative
chronotropic effect
PHARMACOKINETICS
_Absorption_
Bisoprolol is almost completely absorbed from the gastrointestinal
tract and undergoes only
minimal first-pass metabolism resulting in an oral bioavailability of
about 90%. Peak plasma
concentrations occur 2 to 4 hours after oral doses.
_Distribution_
Bisoprolol is about 30% bound to plasma proteins. Bisoprolol is
moderately lipid-soluble.
_Metabolism_
It is metabolised in the liver
_Elimination_
It has a plasma elimination half-life of 10 to 12 hours
It is excreted in urine, about 50% as unchanged drug and 50% as
metabolites
2
INDICATION
For 5mg

Treatment of high blood pressure (hypertension)

Treatment of coronary heart disease (angina pectoris)

Treatment of stable chronic heart failure with reduced systolic left
ventricular function in
addition to ACE inhibitors, and diuretics, and optionally cardiac
glycosides
For 2.5mg

Treatment of stable chronic heart failure with reduced systolic left
ventricular function in
addition to ACE inhibitors, and diuretics, and optionally cardiac
glycosides
RECOMMENDED DOSAGE
_Treatment of hypertension or angina pectoris_
In all cases the dose regimen is adjusted individually by your doctor,
in particular according to
the pulse rate and therapeutic success.