妥泰分散型膠囊１５毫克

Țară: Taiwan

Limbă: chineză

Sursă: 衛生福利部食品藥物管理署 (Ministry of Health and Welfare, Food And Drug Administration)

Ingredient activ:

TOPIRAMATE

Disponibil de la:

嬌生股份有限公司 台北市中山區民生東路三段2號10樓及11樓 (30814854)

Codul ATC:

N03AX11

Forma farmaceutică:

膠囊劑

Compoziție:

TOPIRAMATE (9200038300) MG

Unități în pachet:

塑膠瓶裝

Clasă:

製　劑

Tip de prescriptie medicala:

須由醫師處方使用

Produs de:

CATALENT PHARMA SOLUTIONS LLC 1100 ENTERPRISE DRIVE, WINCHESTER, KENTUCKY 40391, U.S.A. US

Zonă Terapeutică:

topiramate

Indicații terapeutice:

用於成人及二歲以上兒童局部癲癇或併有 LENNOX-GASTAUT症候群之癲癇及原發性全身性強直陣攣癲癇的輔助治療，用於PARTIAL ONSET SEIZURE 病患之單一藥物治療、預防偏頭痛。

Rezumat produs:

有效日期: 2027/02/06; 英文品名: TOPAMAX SPRINKLE CAPSULES 15MG

Data de autorizare:

2002-02-06

Prospect

AED
AED
TOPAMAX
Phenytoin
Carbamazepine
CBZ
Valproic acid
Lamotrigine
Phenobarbital
Primidone
↔
**
↔
↔
↔
↔
↔
↓
48%
↓
40%
↔
↔
NS
NS
↔ 
=
< 15%
**
=
 ↓ 
=
NS =
AED =
Digoxin
TOPAMAX
digoxin
AUC
12%
digoxin
TOPAMAX
digoxin
TOPAMAX
TOPAMAX
1 mg norethindrene
NET
35 mcg ethinyl estradiol
EE
TOPAMAX
TOPAMAX
50~200 mg/day
TOPAMAX
AUC
valproic acid
TOPAMAX
TOPAMAX
200
400
800 mg/day
EE
AUC
18% 21%
30%
TOPAMAX 50 mg/day~800 mg/day
NET
AUC
TOPAMAX
200~800 mg/day
EE
AUC
TOPAMAX
50~200 mg/day
EE
AUC
TOPAMAX
estrogen
Lithium
lithium
topiramate 200 mg/day
lithium
18% for AUC
lithium
topiramate 200 mg/day
lithium
topiramate
600 mg/day
26% for AUC
topiramate
lithium
Risperidone
topiramate
100
250
400 mg/day
risperidone
1
6 mg/day
steady-state AUC
250 mg/day
400 mg/day
16%
33%
risperidone
9-hydroxyrisperidone
9-hydroxyrisperidone
Risperidone
topiramate
Hydrochlorothiazide
HCTZ
HCTZ
25 mg
24
Topiramate
96 mg
12
HCTZ
topiramate
topiramate
C
max
27%
AUC
29%
HCTZ
topiramate
topiramate
HCTZ
topiramate
topiramate
HCTZ
HCTZ
topiramate
Metformin
metformin
metformin
topiramate
metformin
topiramate
metformin
topiramate
metformin
C
max
AUC
0-12h
18%
25%
CL/F
20%
Topiramate
metformin
t
max
Topiramate
metformin
metformin
topiramate
Metformin
topiramate
metformin
TOPAMAX
Pioglitazone
topiramate
pioglitazone
pioglitazone
AUC
,ss
15% C
max,ss
hydroxy-
C
max,ss
AUC
,ss
13%
16%
keto-
C
max,ss
AUC
,ss
60%
TOPAMAX
pioglitazone
pioglitazone
TOPAMAX
Glyburide
glyburide
5 mg/day
topiramate
150 mg/day
Topiramate
glyburide
AUC
24
25%
4-trans-hydroxy-glyburide
M1
3-cis-hydroxyglyburide
M2
13%
15% Topiramate
glyburide
topiramate
glyburide
glyburide
topiramate
TOPAMAX
TOPAMAX
Vitamin K-
topiramate
vitamin K-
酶
Prothrombin Time/International Normalized Ratio, PT/INR
topiramate
vitamin K-
INR
topiramate
C
max
AUC
topiramate
topiramate
topiramate
a
Topiramate
a
Amitriptyline
↔
nortriptyline
C
max
AUC
20%
NS
Dihydroergotamine
↔
↔
Haloperidol
↔
AUC
31%
NS
Propranolol
↔
4-OH propranolol
TPM 50 mg q12h
C
max
17%
C
max
9% 1