TRUPROFEN FLAVORED TAB- carprofen tablet, chewable

País: Estados Unidos

Língua: inglês

Origem: NLM (National Library of Medicine)

Ingredientes ativos:

Carprofen (UNII: FFL0D546HO) (Carprofen - UNII:FFL0D546HO)

Disponível em:

TruRx, LLC

DCI (Denominação Comum Internacional):

Carprofen

Composição:

Carprofen 25 mg

Via de administração:

ORAL

Tipo de prescrição:

PRESCRIPTION

Indicações terapêuticas:

INDICATIONS: Truprofen is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. CONTRAINDICATIONS: TruProfen should not be used in dogs exhibiting previous hypersensitivity to Carprofen.

Resumo do produto:

HOW SUPPLIED: TruProfen (Carprofen) Flavored Tab are scored, and contain 25 mg, 75 mg, or 100 mg of Carprofen per tablet. Each tablet size is packaged in bottles containing 30 or 180 tablets.

Status de autorização:

Abbreviated New Animal Drug Application

Características técnicas

TRUPROFEN FLAVORED TAB- CARPROFEN TABLET, CHEWABLE
TRURX, LLC
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TRUPROFEN
(CARPROFEN) FLAVORED TABLETS
_NON-STEROIDAL ANTI-INFLAMMATORY DRUG_
FOR ORAL USE IN DOGS ONLY
CAUTION: Federal law restricts this drug to use by or on the order of
a licensed
veterinarian.
DESCRIPTION: TruProfen (carprofen) is a non-steroidal
anti-inflammatory drug (NSAID)
of the propionic acid class that includes ibuprofen, naproxen, and
ketoprofen. Carprofen
is the nonproprietary designation for a substituted carbazole,
6-chloro-α-methyl-9H-
carbazole-2-acetic acid. The empirical formula is C
H
ClNO and the molecular weight
273.72. The chemical structure of Carprofen is:
Carprofen is a white, crystalline compound. It is freely soluble in
ethanol, but practically
insoluble in water at 25°C.
CLINICAL PHARMACOLOGY: Carprofen is a non-narcotic, non-steroidal
anti-
inflammatory agent with characteristic analgesic and antipyretic
activity approximately
equipotent to indomethacin in animal models.
The mechanism of action of Carprofen, like that of other NSAIDs, is
believed to be
associated with the inhibition of cyclooxygenase activity. Two unique
cyclooxygenases
have been described in mammals.
The constitutive cyclooxygenase, COX-1,
synthesizes prostaglandins necessary for normal gastrointestinal and
renal function.
The inducible cyclooxygenase, COX-2, generates prostaglandins involved
in
inflammation. Inhibition of COX-1 is thought to be associated with
gastrointestinal and
renal toxicity while inhibition of COX-2 provides anti-inflammatory
activity. The specificity
of a particular NSAID for COX-2 versus COX-1 may vary from species to
species.
In an
_in vitro_ study using canine cell cultures, Carprofen demonstrated
selective inhibition of
COX-2 versus COX-1.
Clinical relevance of these data has not been shown. Carprofen
has also been shown to inhibit the release of several prostaglandins
in two inflammatory
cell systems: rat polymorphonuclear leukocytes (PMN) and human
rheumatoid synovial
cells, indicating inhibition of acute (PMN