T-MULIN 20 200gkg Premix for medicated feeding stuff

País: Malásia

Língua: inglês

Origem: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredientes ativos:

TIAMULIN HYDROGEN FUMARATE

Disponível em:

N.S. LABORATORY SDN. BHD.

DCI (Denominação Comum Internacional):

TIAMULIN HYDROGEN FUMARATE

Unidades em pacote:

500 gm

Fabricado por:

N.S. LABORATORY SDN. BHD.

Características técnicas

N.S.LABORATORY SDN. BHD.
T-MULIN 20, 200g/kg,
Premix for medicated feeding stuff
ACTIVE INGREDIENT:
Each kg contains
Tiamulin (as hydrogen fumarate) ------------------ 200g
PRODUCT DESCRIPTION:
White or almost white powder which is incorporated in animal feeding
stuff
DOSAGE FORM:
Premix for medicated feeding stuff
PHARMACODYNAMICS:
Tiamulin is a bacteriostatic semi-synthetic antibiotic belonging to
the pleuromutilin
group of antibiotics and acts at the ribosomal level to inhibit
bacterial protein
synthesis.
Tiamulin has shown in-vitro activity against a wide range of bacteria
including
_Brachyspira hyodysenteriae_, _ Brachyspira pilosicoli_, _ Lawsonia
intracellularis _ and
_Mycoplasma_ spp.
Tiamulin is bacteriostatic at therapeutic concentrations and has been
shown to
act at the 70S ribosome level and the primary binding site is on the
50S subunit
and possibly a secondary site where the 50S and 30S subunits join. It
appears to
inhibit microbial protein production by producing biochemical inactive
initiation
complexes, which prevent elongation of the polypeptide chain.
Mechanisms responsible for resistance development in _ Brachyspira_
spp to the
pleuromutilin class of antibiotics are considered to be based on
mutations at the
ribosomal
target
site.
Clinically
relevant
resistance
to
tiamulin
requires
combinations
of
mutations
around
the
tiamulin
binding
site.
Resistance
to
tiamulin may be associated with decreased susceptibility to other
pleuromutilins.
PHARMACOKINETICS:
Pigs-
Following
oral
administration,
tiamulin
hydrogen
fumarate
is
rapidly
absorbed from the gastrointestinal tract of pigs (85-90%) and appears
in the
blood within 30 minutes. 2-4 hours (t
max
) after the oral administration of 10 mg
tiamulin/kg BW in the form of an oral solution, a C
max
of 1 µg/ml was measured;
an oral administration of 25 mg/kg gave a C
max
of 1.82 µg/ml.
There is very good distribution in the tissues with accumulation in
lungs and in
the colon. 30-50% of tiamulin is bound to serum proteins. Tiamulin is
rapidly
metabolised