País: Estados Unidos
Língua: inglês
Origem: NLM (National Library of Medicine)
POTASSIUM CHLORIDE (UNII: 660YQ98I10) (POTASSIUM CATION - UNII:295O53K152, CHLORIDE ION - UNII:Q32ZN48698)
B. Braun Medical Inc.
POTASSIUM CHLORIDE
POTASSIUM CHLORIDE 14.9 g in 100 mL
PARENTERAL
PRESCRIPTION DRUG
Potassium Chloride for Injection Concentrate USP is indicated in the treatment of potassium deficiency states when oral replacement is not feasible. This is a concentrated solution which is intended for use in a pharmacy admixture service and is restricted to the preparation of admixtures for intravenous infusion. Potassium Chloride for Injection Concentrate USP is contraindicated in diseases where high potassium levels may be encountered, in patients with hyperkalemia, renal failure and in conditions in which potassium retention is present, or where additives of potassium and chloride could be clinically detrimental.
Potassium Chloride for Injection Concentrate USP (2 mEq K+ /mL) is supplied sterile and nonpyrogenic in 250 mL glass containers with solid stoppers, Pharmacy Bulk Packages, packaged 12 per case. Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat (40°C/104°F). Protect from freezing. It is recommended that the product be stored at room temperature (25°C); however, brief exposure up to 40°C does not adversely affect the product.
Abbreviated New Drug Application
POTASSIUM CHLORIDE- POTASSIUM CHLORIDE INJECTION, SOLUTION, CONCENTRATE B. BRAUN MEDICAL INC. ---------- POTASSIUM CHLORIDE FOR INJECTION CONCENTRATE USP (2 MEQ K /ML) PHARMACY BULK PACKAGE NOT FOR DIRECT INFUSION FOR INTRAVENOUS INFUSION ONLY MUST BE DILUTED PRIOR TO INJECTION DESCRIPTION A pharmacy bulk package is a container of a sterile preparation for parenteral use that contains many single doses. The contents are intended for use in a pharmacy admixture service and are restricted to the preparation of admixtures for intravenous infusion. Potassium Chloride for Injection Concentrate USP is a sterile, nonpyrogenic, concentrated solution of Potassium Chloride USP in Water for Injection USP to be administered by intravenous infusion only after dilution in a larger volume of fluid. No bacteriostatic or antimicrobial agent has been added. Each 100 mL of Potassium Chloride contains: Potassium Chloride USP 14.9 g; Water for Injection USP qs pH: 5.4 (4.0–8.0); Calculated Osmolarity: 4000 mOsmol/liter Concentration of Electrolytes (mEq/mL): Potassium 2; Chloride 2 The formula of the active ingredient is: INGREDIENT MOLECULAR FORMULAMOLECULAR WEIGHT Potassium Chloride USP KCl 74.55 Potassium chloride injection (approximately diluted) is a parenteral fluid and electrolyte replenisher. CLINICAL PHARMACOLOGY Potassium is the chief cation of body cells (160 mEq/liter of intracellular water) and is concerned with the maintenance of body fluid composition and electrolyte balance. Potassium participates in carbohydrate utilization and protein synthesis, and is critical in the regulation of nerve conduction and muscle contraction, particularly in the heart. Chloride, the major extracellular anion, closely follows the metabolism of sodium and changes in the acid-base balance of the body are reflected by changes in the chloride concentration. Normally about 80 to 90% of the potassium intake is excreted in the urine, the + remainder in the stools and to a small extent, in the perspiration. The kidney does not conserve potassi Leia o documento completo