I-Dectin 20mg Chewable Tablet

País: Malásia

Língua: inglês

Origem: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredientes ativos:

IVERMECTIN

Disponível em:

Nam Pharma Sdn. Bhd.

DCI (Denominação Comum Internacional):

IVERMECTIN

Unidades em pacote:

2 x 10 Tablets

Fabricado por:

Nam Pharma Sdn. Bhd.

Características técnicas

I-DECTIN 20MG CHEWABLE TABLET
I-DECTIN 20MG CHEWABLE TABLET appears to be a white to off-white flat
beveled edge round tablet with a score line on one side.
COMPOSITION:
Each chewable tablet of 500 mg contains
Ivermectin 20 mg
PHARMACODYNAMICS:
Ivermectin is a macrocyclic-lactone derivative which has a broad
antiparasitic
activity
against
nematodes
and
arthropods.
It
acts
by
inhibiting
nerve
impulses. Its mode of action includes the glutamate-gated chloride ion
channels. Ivermectin binds selectively and with high affinity to
glutamate-
gated chloride ion channels which occur in invertebrate nerve and
muscle
cells. This leads to an increase in the permeability of the cell
membrane to
chloride ions with hyperpolarisation of the nerve or muscle cell,
resulting in
paralysis and death of the relevant parasites. Compounds of this class
may
also interact with other ligand-gated chloride channels, such as those
gated
by the neurotransmitter gamma-aminobutyric acid (GABA). The high
margin
of safety for compounds of this class is attributable to the fact
that, in
mammals, glutamate receptors in chloride ion channels do not occur;
the
macrocyclic lactones have a low affinity to other mammalian
ligand-gated
chloride ion channels and they do not readily cross the blood-brain
barrier.
PHARMACOKINETICS:
The terminal half-life varies between 2 and 5 days after various
routes of
administrations. Ivermectin is a poorly metabolised compound. Due to
its
lipophilic nature, ivermectin is excreted in bile and ultimately
eliminated from
the body via the faeces. In horses, about 75% of the administered dose
is
excreted via the faeces after an oral administration of ivermectin at
the
recommended dose. Moreover 90% of the total drug is excreted within 4
days
post-administration.
Approximately
2%
of
unchanged
ivermectin
and
metabolites are excreted in urine.
INDICATIONS:
For the treatment of nematode and arthropod infestations, due to adult
and
immature roundworms and bots in horses:

NEMATODES
Large-strongyles:
Strongylus vulgaris (adul