GLYBURIDE tablet

País: Estados Unidos

Língua: inglês

Origem: NLM (National Library of Medicine)

Ingredientes ativos:

GLYBURIDE (UNII: SX6K58TVWC) (GLYBURIDE - UNII:SX6K58TVWC)

Disponível em:

Cardinal Health

DCI (Denominação Comum Internacional):

GLYBURIDE

Composição:

GLYBURIDE 5 mg

Tipo de prescrição:

PRESCRIPTION DRUG

Status de autorização:

Abbreviated New Drug Application

Características técnicas

GLYBURIDE- GLYBURIDE TABLET
CARDINAL HEALTH
----------
GLYBURIDE TABLETS, USP
1.25, 2.5, AND 5 MG
DESCRIPTION
Glyburide tablets USP contain glyburide, USP, which is an oral
blood-glucose-lowering drug of the
sulfonylurea class. Glyburide, USP is a white, crystalline compound.
The chemical name for glyburide,
USP is
1-[[p-[2-(5-chloro-o-anisamido)ethyl]phenyl]-sulfonyl]-3-cyclohexylurea.
It has the following
structural formula:
C
H ClN O S M.W. 493.99
Each tablet, for oral administration, contains 1.25 mg, 2.5 mg or 5 mg
of glyburide, USP. In addition,
each tablet contains the following inactive ingredients:
microcrystalline cellulose, pregelatinized corn
starch, sodium starch glycolate, colloidal silicon dioxide, and
magnesium stearate. In addition, the 2.5
MG contains FD&C yellow No. 6 aluminum lake and the 5 MG contains D&C
yellow No. 10 aluminum
lake, and FD&C blue No. 1 aluminum lake.
CLINICAL PHARMACOLOGY
ACTIONS
Glyburide appears to lower the blood glucose acutely by stimulating
the release of insulin from the
pancreas, an effect dependent upon functioning beta cells in the
pancreatic islets. The mechanism by
which glyburide lowers blood glucose during long-term administration
has not been clearly
established. With chronic administration in Type II diabetic patients,
the blood glucose lowering effect
persists despite a gradual decline in the insulin secretory response
to the drug. Extrapancreatic effects
may be involved in the mechanism of action of oral sulfonylurea
hypoglycemic drugs. The combination
of glyburide and metformin may have a synergistic effect, since both
agents act to improve glucose
tolerance by different but complementary mechanisms.
Some patients who are initially responsive to oral hypoglycemic drugs,
including glyburide, may
become unresponsive or poorly responsive over time. Alternatively,
glyburide tablets may be effective
in some patients who have become unresponsive to one or more other
sulfonylurea drugs.
In addition to its blood glucose lowering actions, glyburide produces
a mild