DEXAMETHASONE SOLUTION - dexamethasone solution injection, solution

País: Estados Unidos

Língua: inglês

Origem: NLM (National Library of Medicine)

Ingredientes ativos:

DEXAMETHASONE (UNII: 7S5I7G3JQL) (DEXAMETHASONE - UNII:7S5I7G3JQL)

Disponível em:

Med-Pharmex, Inc

Tipo de prescrição:

PRESCRIPTION

Indicações terapêuticas:

INDICATIONS: Dexamethasone Solution is indicated for the treatment of primary bovine ketosis and as an anti-inflammatory agent in the bovine and equine.  As supportive therapy, Dexamethasone Solution may be used in the management of various rheumatic, allergic, dermatologic, and other diseases known to be responsive to anti-inflammatory corticosteroids. Dexamethasone Solution may be used intravenously as supportive therapy when an immediate hormonal response is required.  Bovine Ketosis Dexamethasone Solution is offered for the treatment of primary ketosis.  The gluconeogenic effects of dexamethasone, when administered intramuscularly, are generally noted within the first six to twelve hours.  When Dexamethasone Solution is used intravenously, the effects may be noted sooner.  Blood sugar levels rise to normal levels rapidly and generally rise to above normal levels within 12 to 24 hours.  Acetone bodies are reduced to normal concentrations usually within 24 hours.  The physical attitude of animals t

Resumo do produto:

HOW SUPPLIED: Dexamethasone Solution, 2 mg/mL, 100 mL multiple dose vial. Store between 20° - 25°C (68° - 77° F) . Med-Pharmex, Inc. Pomona, CA 91767-1861 Rev 2/12

Status de autorização:

Abbreviated New Animal Drug Application

Características técnicas

DEXAMETHASONE SOLUTION - DEXAMETHASONE SOLUTION INJECTION, SOLUTION
MED-PHARMEX, INC
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DEXAMETHASONE SOLUTION
NDC 54925-067-10
DEXAMETHASONE SOLUTION
2 mg/mL
For Intravenous or Intramuscular Injection
Veterinarian
For Animal Use Only
Keep Out Of Reach Of Children
CAUTION:
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
ANADA# 200-456, Approved by FDA
DESCRIPTION:
Dexamethasone is a synthetic analogue of prenisolone, having similar
but more potent anti-inflammatory
therapeutic action and diversified hormonal and metabolic effects.
Modification of the basic corticoid
structure as achieved in Dexamethasone Solution offers enhanced
anti-inflammatory effect compared to
older corticosteroids. The dosage of Dexamethasone Solution required
is markedly lower than that of
prednisone and prednisolone.
Dexamethasone Solution is not species-specific; however, the
veterinarian should read the sections on
INDICATIONS, DOSAGE, SIDE EFFECTS, CONTRAINDICATIONS, PRECAUTIONS, and
WARNINGS before this drug is used.
Dexamethasone Solution is intended for _intravenous_ or _intramuscular
_ administration. Each mL contains
2 mg dexamethasone, 500 mg polyethylene glycol 400, 9 mg benzyl
alcohol, 1.8 mg methylparaben and
0.2 mg propylparaben as preservatives, 4.75% alcohol, HCl and/or
sodium hydroxide to adjust pH to
approximately 4.9, Water for Injection q.s.
EXPERIMENTAL STUDIES:
Experimental animal studies on dexamethasone have revealed that it
possesses greater anti-inflammatory
activity than many steroids. Veterinary clinical evidence indicates
dexamethasone has approximately
twenty times the anti-inflammatory activity of prednisolone and 70 to
80 times that of hydrocortisone.
Thymus involution studies show dexamethasone possesses 25 times the
activity of prednisolone. In
reference to mineralocorticoid activity, dexamethasone does not cause
significant sodium or water
retention. Metabolic balance studies show that animals on controlled
and limited protein intake will
exhibit nitrogen loss