Condrosa Sachet for oral solution

País: Malásia

Língua: inglês

Origem: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Ingredientes ativos:

Glucosamine Sulfate Sodium Chloride; CHONDROITIN SULFATE

Disponível em:

AV MANUFACTURING SDN.BHD

DCI (Denominação Comum Internacional):

Glucosamine Sulfate Sodium Chloride; CHONDROITIN SULFATE

Unidades em pacote:

5.72g X 3 sachet Sachets; 5.72g X14 sachet Sachets

Fabricado por:

AV MANUFACTURING SDN.BHD

Características técnicas

CONDROSA SACHET FOR ORAL SOLUTION
NAME AND STRENGTH OF ACTIVE SUBSTANCES
Glucosamine sulphate sodium chloride 1884 mg (derived from seafood)
equivalent 1500 mg glucosamine
sulphate and chondroitin sulphate 1200 mg (as chondroitin sulphate
1333 mg 90% potency, derived from fish
).
PRODUCT DESCRIPTION
Condrosa sachet is off-white to beige powder with yellow beads lemon
flavour to be dissolved
in water which forms a clear solution.
PHARMACODYNAMICS
Glucosamine is a natural substance found in chitin, mucoproteins, and
mucopolysaccharides. It is involved in
the manufacture of glycosaminoglycan, which forms cartilage tissue in
the body; glucosamine is also present
in tendons and ligaments. Glucosamine must be synthesised by the body
but the ability to do this declines with
age. Glucosamine and its salts have therefore been advocated in the
treatment of rheumatic disorders including
osteoarthritis.
Glucosamine also acts to improve the viscosity of synovial fluid by
increasing synovial fluid production,
thereby providing lubricant activity.
The primary mechanism of action of Chondroitin Sulphate is increased
joint glycosaminoglycan
concentration and a subsequent enhancement of synovial fluid
viscosity. Improvement in joint structure
and function are due to: (1) increased endogenous synthesis of
hyaluronic acid and sulfated
glycosaminoglycans from chondroitin sulfates; and (2) reduced
breakdown of joint glycosaminoglycans
subsequent to decreased collagenolytic activity and inhibition of
enzymes, such as phospholipase A2 and
N-acetylglucosaminidase, which are capable of degrading existing joint
glycosaminoglycans.
Glucosamine and chondroitin work synergistically to stimulate the
anabolic metabolism of osteo-
cartilagineous tissues by stimulating the biosynthesis of the
mucopolysaccharides (which are the essential
components of the cartilage ground substance).
PHARMACOKINETICS
_Absorption_
After oral administration, bioavailability of glucosamine sulphate is
low due to first-pass hepatic
metabolism~26%. The gastrointestinal