País: Malásia
Língua: inglês
Origem: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
CLARITHROMYCIN
KOTRA PHARMA (M) SDN. BHD.
CLARITHROMYCIN
60ml mL
KOTRA PHARMA (M) SDN. BHD.
AXCEL CLARITHROMYCIN-125 SUSPENSION Clarithromycin 125mg/5ml 1 _CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP) _ WHAT IS IN THIS LEAFLET 1. What Axcel Clarithromycin-125 Suspension is used for. 2. How Axcel Clarithromycin-125 Suspension works. 3. Before you use Axcel Clarithromycin-125 Suspension. 4. How to use Axcel Clarithromycin- 125 Suspension. 5. While you are using it. 6. Side effects. 7. Storage and disposal of Axcel Clarithromycin-125 Suspension. 8. Product description. 9. Manufacturer and Product Registration Holder. 10. Date of revision. WHAT AXCEL CLARITHROMYCIN-125 SUSPENSION IS USED FOR Axcel Clarithromycin-125 Suspension is used to treat infections due to susceptible organisms of the: • Upper respiratory infection of nose- pharynx and paranasal sinuses. • Lower respiratory tract infections. • Acute otitis media. • Skin and skin structure infections. HOW AXCEL CLARITHROMYCIN-125 SUSPENSION WORKS Clarithromycin is a semi-synthetic macrolide antibiotic with a primarily bacteriostatic action against bacteria. BEFORE YOU USE AXCEL CLARITHROMYCIN- 125 SUSPENSION _-When you must not use it _ Do not take Axcel Clarithromycin-125 Suspension if: • You are having impaired renal or hepatic function. • It is not prescribed by a qualified doctor or pharmacist for you. • You are pregnant, trying to get pregnant or think you may be pregnant. • You are breast-feeding. Ask your doctor or pharmacist for advice before taking any medicine. • You are taking any of the following medicines: domperidone (used for nausea & vomiting). _ _ _ _ _ _ _-Before you start to use it _ Tell your doctor if: • If you are allergic to any medicines, food and dyes. • If you are taking any other medicines (including those not prescribed by your doctor). • If you are pregnant or nursing babies. _-Taking other medicines _ You should tell your doctor if you are taking the following medicine as it may interact with your Axcel Clarithromycin- 125 Suspension: • Carbamazepine and theopylline. • Drug metabolized by the Leia o documento completo
CLARITHROMYCIN-125 COMPOSITION: Each 5ml contains Clarithromycin 125mg PRESENTATION: White color granules which gives a white colored suspension with fruit flavor when reconstituted. INDICATIONS: Treatment of infection due to susceptible organism of the upper respiratory infection of nose-pharynx (tonsillitis, pharyngitis) and of paranasal sinuses; lower respiratory tract infections: bronchitis, bacterial pneumonia and atypical pneumonia. Acute otitis media. Skin & skin structure infections: impetigo, erysipelas, folliculitis, furunculosis and septic wounds. PHARMACOLOGY: _Mechanism of Action:_ Clarithromycin is a semi-synthetic macrolide antibiotic with a primarily bacteriostatic action against many Gram-positive and to a lesser extent some Gram-negative bacteria, as well as other organism including mycloplasma, spirochaetes, chlamydiae, and rickettsia. Clarithromycin and other macrolides bind reversibly to the 50s subunit of the ribosome, resulting in blockage of the transpeptidation or translocation reactions, inhibition of protein synthesis and hence inhibition of cell growth. Its action is predominantly bacteriostatic, but high concentrations are slowly bactericidal against the more sensitive strains. Because of the ready penetration of macrolides into white blood cells and macrophages there has been some interest in their potential synergy with host defense mechanisms _in _ _vivo_. Clarithromycin active against susceptible streptococci and staphylococci _ in vitro_, as well as against some other species including _Moraxella _ _(Branhamella) _ _catarrhalis, _ _Legionella _ _spp., _ _Chlamydia trachomatis and Ureaplasma urealyticum_. Clarithromycin is reported to be active against some opportunistic mycobacteria, including _Mycobacterium _ _avium_ _complex_, and against _M.leprae_. It is also have some _in _ _vitro_ activity against the protozoan _Toxoplasma gondii_, and many have some activity against cryptosporidium. The major metabolite, 14-hydroxyclarithromycin, is also active, and many enhance the activi Leia o documento completo