País: Nova Zelândia
Língua: inglês
Origem: Medsafe (Medicines Safety Authority)
Amyl nitrite 98%{relative}
Baxter Healthcare Ltd
Amyl nitrite 98% w/v
98% w/v
Volatile liquid for inhalation
Active: Amyl nitrite 98%{relative} Excipient: Epoxidised linseed oil
Ampoule, glass, crushable, in boxes of 12, 3.6 mL
Prescription
Prescription
James Alexander Corporation
Package - Contents - Shelf Life: Ampoule, glass, crushable, in boxes of 12 - 3.6 mL - 24 months from date of manufacture stored at 8° to 15°C (Cool) 36 months from date of manufacture stored at 2° to 8°C (Refrigerate, do not freeze)
1992-08-19
DATA SHEET AMYL NITRITE _INHALANT _ PRESENTATION Amyl nitrite is a rapidly acting vasodilator administered by inhalation. 0.3mL is supplied in a covered thin glass capsule which is easily crushed between the fingers. Amyl nitrite is a clear, yellowish liquid having a peculiar ethereal, fruity odour. It is volatile, even at low temperatures, and is flammable. This product is 98% w/v, stabilized with Epoxol 9- 5, 2%w/v. The structural formula of amyl nitrite is (CH 3 ) 2 CHCH 2 CH 2 ONO. USES _ACTIONS _ Amyl nitrite causes a non-specific relaxation of smooth muscle with the most prominant actions occurring in vascular smooth muscle. This effect on vascular smooth muscle results in coronary vasodilation and decreased systemic vascular resistance and left ventricular preload and afterload. Additionally, amyl nitrite induces the formation of methemoglobin. In cases of cyanide poisoning, the methemoglobin combines with the cyanide to form nontoxic cyanmethemoglobin. _PHARMACOKINETICS _ Amyl nitrite vapours are absorbed rapidly through the pulmonary alveoli, manifesting therapeutic effects within one minute after inhalation. The drug is metabolised rapidly, probably by hydrolytic denitration; approximately one third of the inhaled amyl nitrite is excreted in the urine. INDICATIONS Amyl nitrite is indicated for the treatment of cyanide poisoning in the conscious patient. DOSAGE AND ADMINISTRATION With the patient in a recumbent or seated position a capsule of amyl nitrite is crushed between the fingers and held under the patient's nose. Inhalations should be administered for up to 30 seconds every 2 minutes, using a fresh capsule each time until signs of recovery occur. Up to 8 capsules may be given if there is a delay in administering intravenous antidotes. Safety and effectiveness in Leia o documento completo