Amaryl

País: Austrália

Língua: inglês

Origem: Department of Health (Therapeutic Goods Administration)

Ingredientes ativos:

Glimepiride

Disponível em:

Sanofi-Aventis Australia Pty Ltd

Classe:

Medicine Registered

Folheto informativo - Bula

AMARYL
®

_(AM-A(R)-RILL)_
_glimepiride (glim-epi-RIDE)_
CONSUMER MEDICINE INFORMATION (CMI)

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Amaryl.
It does not contain all the available
information. It does not take the
place of talking to your doctor,
pharmacist or diabetes educator.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking Amaryl
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT AMARYL IS USED
FOR
Amaryl is used to control blood
glucose in patients with type 2
diabetes mellitus.
Amaryl is used when healthy eating
and increased physical activity are
not enough to control your blood
glucose.
Amaryl can be used alone, or
together with insulin or other
medicines for treating diabetes.
_HOW IT WORKS_
Amaryl lowers high blood glucose by
increasing the amount of insulin
produced by your pancreas.
Amaryl belongs to a group of
medicines called sulfonylureas.
If your blood glucose in not
controlled properly, you may
experience hypoglycaemia (low
blood glucose - a "hypo") or
hyperglycaemia (high blood
glucose).
Low blood glucose can occur
suddenly. Signs may include:
•
weakness, trembling or shaking
•
sweating
•
lightheadedness, dizziness,
headache or lack of concentration
•
tearfulness or crying
•
irritability
•
hunger
•
numbness around the lips and
tongue
If not treated promptly, these may
progress to:
•
loss of co-ordination
•
slurred speech
•
confusion
•
loss of consciousness or seizures
High blood glucose usually occurs
more slowly than low blood glucose.
Signs of high blood glucose may
include:
•
lethargy or tiredness
•
headache
•
thirst
•
passing large amounts of urine
•
blurred vision
High blood glucose can lead to
serious problems with your heart,
eyes, circulation or kidneys.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY THIS ME

Características técnicas

PRODUCT INFORMATION  
Amaryl - glimepiride 

amaryl-ccdsv12-piv10-09apr13

1 
PRODUCT INFORMATION 
AMARYL 
NAME OF THE MEDICINE 
Amaryl 
AUSTRALIAN APPROVED NAME 
Glimepiride 
CHEMICAL STRUCTURE 
Amaryl tablets contain glimepiride which is a member of the
sulfonylurea group of oral 
antidiabetic agents.  
Molecular Formula: C
24
H
34
N
4
0
5
S 
Molecular Weight: 491 
Chemical Name: trans-1-{4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1
carboxamido) ethyl]-
phenylsulfonyl}-3-(4-methylcyclohexyl) urea 

CAS REGISTRY NUMBER 
93479-97-1 
DESCRIPTION 
Glimepiride is a white odourless, crystalline powder,
practically insoluble in methanol and water, 
slightly soluble in ethanol and sparingly soluble in methylene
chloride. 
PRODUCT INFORMATION  
Amaryl - glimepiride 

amaryl-ccdsv12-piv10-09apr13

2 
Each Amaryl tablet contains glimepiride as active ingredient and
the excipients: lactose, sodium 
starch glycollate, povidone, microcrystalline cellulose and
magnesium stearate. Additionally, each 
strength contains identifying pigment, viz: 1 mg tablet: iron
oxide red; 2 mg tablet: iron oxide 
yellow and indigo carmine lake; 3 mg tablet: iron oxide yellow;
4 mg tablet: indigo carmine lake. 
PHARMACOLOGY 
PHARMACODYNAMICS 
MECHANISM OF ACTION 
Glimepiride is a sulfonylurea anti-diabetic agent which decreases
blood glucose concentrations. 
The primary mechanism of action of glimepiride appears to be
dependent on stimulating the 
release of insulin from functioning pancreatic beta cells.
Glimepiride acts in concert with glucose 
by improving the sensitivity of beta cells to physiological
glucose stimulus, resulting in insulin 
secretion in the rhythm of meals. In addition, extrapancreatic
effects (e.g. reduction of basal 
hepatic glucose production and increased peripheral
tissue sensitivity to insulin and glucose 
uptake) may also play a limited role in the activity of
glimepiride. 
In non-fasting diabet