T.O. Prazosin 2 mg Tablet

Kraj: Malezja

Język: angielski

Źródło: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Składnik aktywny:

PRAZOSIN HYDROCHLORIDE

Dostępny od:

GoodScience Sdn. Bhd.

INN (International Nazwa):

PRAZOSIN HYDROCHLORIDE

Sztuk w opakowaniu:

100Tablet Tablets; 250Tablet Tablets

Wyprodukowano przez:

T.O. PHARMA CO LTD

Ulotka dla pacjenta

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
T.O. PRAZOSIN TABLET
Prazosin hydrochloride (1mg, 2mg)
1
WHAT IS IN THIS LEAFLET
1.
What T.O. Prazosin is used for
2.
How T.O. Prazosin works
3.
Before you use T.O. Prazosin
4.
How to use T.O. Prazosin
5.
While you are using it
6.
Side Effects
7.
Storage and Disposal of T.O. Prazosin
8.
Product Description
9.
Manufacturer and Product Registration
Holder
10.
Date of Revision
WHAT T.O. PRAZOSIN IS USED FOR
T.O. Prazosin is usually used to treat high
blood pressure (hypertension).
It may also be used to treat
heart failure (left
ventricle-related), Raynaud’s disease (where
the fingers become white and painful when
cold) or enlargement of the prostate gland
(benign prostatic hyperplasia) in men.
When used to treat high blood pressure or
heart failure, T.O. Prazosin is often used in
combination with other medicines.
HOW T.O. PRAZOSIN WORKS
T.O. Prazosin contains the active substance
Prazosin hydrochloride. It belongs to a group
of medicines called alpha-blockers. It works
by relaxing muscles in the walls of blood
vessels and reducing the resistance to blood
flow. It also relieves prostate problems by
relaxing muscles in the prostate gland and
increasing the flow of urine.
BEFORE YOU USE T.O. PRAZOSIN_ _
-
_When you must not use it_
Do not take T.O. Prazosin if you:
• Have ever had allergic reaction to Prazosin
hydrochloride,
any
related
medicine
or
to
any other ingredients listed at the end of this
leaflet.
_If you are not sure whether you should start _
_taking this medicine, consult your doctor. _
-
_Before you start to use it _
Tell your doctor if you have allergies to any
other medicines, food, preservatives or dyes.
Tell your doctor if you:
• Suffer from any form of heart disease that
involved
damages
to
the
heart
valve,
or
obstruction
to
the
blood
flow
such
as
pulmonary
embolism
or
restrictive
pericardial disease.
• Have been given other medicines to treat
high blood pressure.
•
Have a family history of swelling of the
face, lips, tongue, throat, hands

Charakterystyka produktu

DESCRIPTION:
T.O. Prazosin 1 mg Tablet: An orange, round biconvex tablet with a
breakline on one side. Each tablet contains prazosin hydrochloride
(HCl) 1.095 mg (equivalent to prazosin 1 mg).
T.O. Prazosin 2 mg Tablet: A white round biconvex tablet with a
breakline and a figure “2” on one side and the letters “TOC”
on the
other. Each tablet contains prazosin HCl 2.190 mg (equivalent to
prazosin 2 mg).
PHARMACODYNAMICS
Prazosin is an orally active post-synaptic selective alpha
adrenoceptor
antagonist which reduces peripheral vascular resistance and blood
pressure as a result of its vasodilating effects. It produces both
arterial
and venous dilation.
PHARMACOKINETICS
Prazosin is readily absorbed from the gastrointestinal tract with peak
plasma concentrations occurring 1 to 3 hours after an oral dose. The
bioavailability is variable and a range of 43 to 85 % has been
reported.
Prazosin is highly bound to plasma proteins. It is extensively metabo-
lised in the liver, primarily by demethylation and conjugation and is
excreted, as metabolites and unchanged prazosin (5 to 11 %), mainly
in the faeces via the bile. Less than 10 % is excreted in the urine.
Small
amounts are distributed into breast milk. Its duration of action is
longer than would be predicted from its relatively short plasma
half-life of about 2 to 4 hours. Half-life is reported to be increased
to
about 7 hours in patients with heart failure.
INDICATIONS
Hypertension
T.O. Prazosin 1 mg / 2 mg Tablet is indicated in the treatment of all
grades of essential (primary) hypertension and all grades of second-
ary hypertension of varied aetiology. It can be used as the initial
and
sole agent or it may be employed in a treatment program in conjunc-
tion with a diuretic and/or other antihypertensive drugs, as needed,
for proper patient response.
Left Ventricular Failure
T.O. Prazosin 1 mg / 2 mg Tablet is indicated in the treatment of left
ventricular failure. Prazosin hydrochloride may be added to the thera-
peutic
regimen
in
patients
who
have
not
shown
a