Kraj: Izrael
Język: angielski
Źródło: Ministry of Health
DESFLURANE
BAXTER HEALTHCARE DISTRIBUTION LTD., ISRAEL
N01AB07
SOLUTION FOR INHALATION
DESFLURANE 100 %
INHALATION
Required
BAXTER HEALTHCARE CORPORATION, USA
DESFLURANE
DESFLURANE
Sulorane is indicated as an inhalation agent for induction and/or maintenance of anesthesia in adults and maintenance of anesthesia in infants and children.
2021-05-31
העדוה העדוה לע לע הרמחה הרמחה ( ( עדימ עדימ ןולעב )תוחיטב ןולעב )תוחיטב ל ל אפור אפור ןכדועמ( 05/2013 ) ךיראת _______ MARCH 3, 2015 __ םש רישכת תילגנאב ירפסמו םושירה SULORANE SOLUTION FOR INHALATION 101 32 28466 00 םש לעב םושירה TEVA MEDICAL MARKETING LTD., HAORGIM ST 8 ASHDOD 77100 ספוט הז דעוימ טורפל תורמחה דבלב ! תורמחהה תושקובמה קרפ ןולעב טסקט יחכונ טסקט שדח INDICATION CONTRAINDICATIONS Desflurane should not be used for anaesthetic induction in patients at risk of coronary artery disease or in patients where increases in heart rate or blood pressure are undesirable. Desflurane should not be used for anaesthetic induction in patients at risk of coronary artery disease or in patients where increases in heart rate or blood pressure are undesirable. Desflurane is contraindicated in patients with a history of confirmed hepatitis due to a halogenated inhalational anaesthetic or with a history of unexplained moderate to severe hepatic dysfunction (e.g., jaundice associated with fever and/or eosinophilia) after anaesthesia with a halogenated inhalational anaesthetic. Desflurane is contraindicated for use as an inhalation induction agent in paediatric patients because of the frequent occurrence of cough, breath holding, apnoea, laryngospasm, and increased secretions . POSOLOGY, DOSAGE & ADMINISTRATION Induction of Anaesthesia in Adults In adults, a starting concentration of 3% is recommended, increased in 0.5- 1.0% increments every 2 to 3 breaths. Inspired concentrations of 4-11% of desflurane usually produce surgical anaesthesia in 2-4 minutes. Higher concentrations up to 15% may be used. Such concentrations of desflurane will proportionately dilute the concentration of oxygen and commencing administration of oxygen should be 30% or above. After induction in adults with an intravenous drug such as thiopental or propofol, desflurane can be star Przeczytaj cały dokument
1 PHYSICIAN'S PRESCRIBING INFORMATION 1. NAME OF THE MEDICINAL PRODUCT Suprane 2. QUALITATIVE AND QUANTITATIVE COMPOSITION Desflurane, supplied as pure drug substance 3. PHARMACEUTICAL FORM Solution for inhalation 4. CLINICAL PARTICULARS 4.1 Therapeutic indications Suprane is indicated as an inhalation agent for induction and/or maintenance of anaesthesia in adults and maintenance of anaesthesia in infants and children. 4.2 Posology and method of administration Method of administration Desflurane is administered by inhalation. Desflurane should only be administered by persons trained in the administration of general anaesthesia using a vaporizer specifically designed and designated for use with desflurane. Premedication Premedication should be selected according to the needs of the individual patient taking into account that salivary secretions are stimulated. The use of anticholinergic drugs is a matter of choice for the anaesthetist. Individualization The administration of general anaesthesia must be individualized based on the patient's response. Effects on Concomitant Therapy Opioids or benzodiazepines decrease the amount of desflurane required to produce anaesthesia. Desflurane decreases the required doses of neuromuscular blocking agents (see Table 2, section 4.5). If added relaxation is required, supplemental doses of muscle relaxants may be used (See section 4.5). Dosage 2 The minimum alveolar concentration (MAC) of desflurane decreases with increasing patient age. The dose of desflurane should be adjusted accordingly. The MAC has been determined as listed in Table 1. Table 1: MAC for desflurane according to patient age and inhalation mixture (Mean ± SD) Age N* 100% Oxygen N* 60% Nitrous Oxide/40% Oxygen 2 weeks 6 9.2 ± 0.0 - - 10 weeks 5 9.4 ± 0.4 - - 9 months 4 10.0 ± 0.7 5 7.5 ± 0.8 2 years 3 9.1 ± 0.6 - - 3 years - - 5 6.4 ± 0.4 4 years 4 8.6 ± 0.6 - - 7 years 5 8.1 ± 0.6 - - 25 years 4 7.3 ± 0.0 4 4.0 ± 0.3 45 years 4 6.0 ± 0.3 6 2.8 ± 0.6 70 years 6 5.17 ± 0.6 6 1.67 ± 0.4 N*= number Przeczytaj cały dokument