SEVOFLURANE BAXTER 100 % INHALATION VAPOUR LIQUID

Kraj: Izrael

Język: angielski

Źródło: Ministry of Health

Składnik aktywny:

SEVOFLURANE

Dostępny od:

BAXTER HEALTHCARE DISTRIBUTION LTD., ISRAEL

Kod ATC:

N01AB08

Forma farmaceutyczna:

LIQUID FOR INHALATION

Skład:

SEVOFLURANE 100 %V/V

Droga podania:

INHALATION

Typ recepty:

Required

Wyprodukowano przez:

BAXTER S.A., BELGIUM

Dziedzina terapeutyczna:

SEVOFLURANE

Wskazania:

Sevoflurane is indicated for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Data autoryzacji:

2021-09-12

Charakterystyka produktu

1
SEVOFLURANE BAXTER 100 % INHALATION VAPOUR LIQUID
(SEVOFLURANE 100% V/V)
LIQUID FOR INHALATION
THERAPEUTIC INDICATIONS
Sevoflurane is indicated for induction and maintenance of general
anesthesia in adult and
pediatric patients for inpatient and outpatient surgery.
DESCRIPTION
Sevoflurane, volatile liquid for inhalation, a nonflammable and
nonexplosive liquid
administered by vaporization, is a halogenated general inhalation
anesthetic drug.
Sevoflurane is fluoromethyl 2,2,2,-trifluoro-1-(trifluoromethyl) ethyl
ether and its structural
formula is:
SEVOFLURANE, PHYSICAL CONSTANTS ARE:
Molecular weight
200.05
Boiling point at 760 mm Hg
58.6°C
Specific gravity at 20°C
1.520-1.525
Vapor pressure in mm Hg
157 mm Hg at 20°C
2
197 mm Hg at 25°C
317 mm Hg at 36°C
DISTRIBUTION PARTITION COEFFICIENTS AT 37°C:
Blood/Gas
0.63-0.69
Water/Gas
0.36
Olive Oil/Gas
47 – 54
Brain/Gas
1.15
MEAN COMPONENT/GAS PARTITION COEFFICIENTS AT 25°C FOR POLYMERS USED
COMMONLY IN
MEDICAL APPLICATIONS:
Conductive rubber
14.0
Butyl rubber
7.7
Polyvinylchloride
17.4
Polyethylene
1.3
Sevoflurane is nonflammable and nonexplosive as defined by the
requirements of International
Electrotechnical Commission 601-2-13.
Sevoflurane is a clear, colorless liquid containing no additives.
Sevoflurane is not corrosive to
stainless steel, brass, aluminum, nickel-plated brass, chrome-plated
brass or copper beryllium.
Sevoflurane is nonpungent. It is miscible with ethanol, ether,
chloroform, and benzene, and it is
slightly soluble in water. Sevoflurane is stable when stored under
normal room lighting
conditions according to instructions. No discernible degradation of
sevoflurane occurs in the
presence of strong acids or heat. When in contact with alkaline CO
2
absorbents (e.g., Baralyme
®
and to a lesser extent soda lime) within the anesthesia machine,
sevoflurane can undergo
degradation under certain conditions. Degradation of sevoflurane is
minimal, and degradants are
either undetectable or present in non-toxic amounts when used as
directed with fresh