propranolol hydrochloride- Propranolol Hydrochloride injection

Kraj: Stany Zjednoczone

Język: angielski

Źródło: NLM (National Library of Medicine)

Składnik aktywny:

propranolol hydrochloride (UNII: F8A3652H1V) (Propranolol - UNII:9Y8NXQ24VQ)

Dostępny od:

Baxter Healthcare Corporation

INN (International Nazwa):

Propranolol Hydrochloride

Forma farmaceutyczna:

INJECTION

Skład:

1 mg in 1 mL

Droga podania:

INTRAVENOUS

Typ recepty:

PRESCRIPTION DRUG

Wskazania:

Intravenous administration is usually reserved for life-threatening arrhythmias or those occurring under anesthesia. - Supraventricular arrhythmiasIntravenous propranolol is indicated for the short-term treatment of supraventricular tachycardia, including Wolff-Parkinson-White syndrome and thyrotoxicosis, to decrease ventricular rate. Use in patients with atrial flutter or atrial fibrillation should be reserved for arrythmias unresponsive to standard therapy or when more prolonged control is required. Reversion to normal sinus rhythm has occasionally been observed, predominantly in patients with sinus or atrial tachycardia.

Podsumowanie produktu:

Each mL contains 1 mg of propranolol hydrochloride in Water for Injection. The pH is adjusted with citric acid. Supplied as: 1 mL ampuls in boxes of 10 (NDC 10019-145-01). Store at controlled room temperature 20° to 25°C (68° to 77°F). Protect from freezing or excessive heat. Manufactured by Baxter Healthcare Corporation Deerfield, IL 60015 USA For Product Inquiry 1 800 ANA DRUG (1-800-262-3784) MLT-01594/2.0

Charakterystyka produktu

PROPRANOLOL HYDROCHLORIDE- PROPRANOLOL HYDROCHLORIDE INJECTION
BAXTER HEALTHCARE CORPORATION
----------
RX ONLY
DESCRIPTION
Propranolol hydrochloride is a synthetic beta-adrenergic receptor
blocking agent chemically described
as (+)-1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride.
Its structural formula is:
Propranolol hydrochloride is a stable, white, crystalline solid which
is readily soluble in water and
ethanol. Its molecular weight is 295.80.
Propranolol hydrochloride injection is available as a sterile
injectable solution for intravenous
administration. Each mL contains 1 mg of propranolol hydrochloride in
Water for Injection. The pH is
adjusted with citric acid.
CLINICAL PHARMACOLOGY
GENERAL
Propranolol is a nonselective beta-adrenergic receptor blocking agent
possessing no other autonomic
nervous system activity. It specifically competes with beta-adrenergic
receptor stimulating agents for
available receptor sites. When access to beta-receptor sites is
blocked by propranolol, chronotropic,
inotropic, and vasodilator responses to beta-adrenergic stimulation
are decreased proportionately. At
doses greater than required for beta blockade, propranolol also exerts
a quinidine-like or anesthetic-
like membrane action, which affects the cardiac action potential. The
significance of the membrane
action in the treatment of arrhythmias is uncertain.
MECHANISM OF ACTION
The effects of propranolol are due to selective blockade of
beta-adrenergic receptors, leaving alpha-
adrenergic responses intact. There are two well-characterized subtypes
of beta receptors (beta
and
beta ); propranolol interacts with both subtypes equally. Beta
-adrenergic receptors are found primarily
in the heart. Blockade of cardiac beta -adrenergic receptors leads to
a decrease in the activity of both
normal and ectopic pacemaker cells and a decrease in A-V nodal
conduction velocity. All of these
actions can contribute to antiarrhythmic activity and control of
ventricular rate during arrhythmias.
Blockade of cardiac beta -adrenerg