Primaxin

Kraj: Australia

Język: angielski

Źródło: Department of Health (Therapeutic Goods Administration)

Składnik aktywny:

Cilastatin; Imipenem

Ulotka dla pacjenta

PRIMAXIN(R)
1
PRIMAXIN(R)
_Imipenem/Cilastatin sodium_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about PRIMAXIN.  It does
not contain all the available
information.
It does not take the place of talking
to your doctor or pharmacist.
All medicines have risks and
benefits.  Your doctor has weighed
the risks of you using PRIMAXIN
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
BEING GIVEN THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET.
You may need to read it again.
WHAT PRIMAXIN IS
USED FOR
PRIMAXIN is an antibiotic which is
used to treat serious infections
caused by bacteria (germs).  These
infections may occur in many
different parts of the body.
PRIMAXIN is sometimes given in
addition to other antibiotics.
PRIMAXIN works by killing the
bacteria causing the infection.
BEFORE YOU ARE GIVEN
PRIMAXIN
_WHEN YOU MUST NOT BE GIVEN_
_IT_
DO NOT USE PRIMAXIN IF YOU HAVE
AN ALLERGY TO PRIMAXIN OR ANY OF
THE INGREDIENTS LISTED AT THE END OF
THIS LEAFLET.
_BEFORE YOU ARE GIVEN IT_
TELL YOUR DOCTOR IF:
1. YOU ARE PREGNANT OR ARE
BREAST-FEEDING
Your doctor will discuss the
possible risks and benefits of
using PRIMAXIN during
pregnancy and breast-feeding.
PRIMAXIN passes into breast
milk and may be passed on to the
baby.
2. YOU HAVE ANY MEDICAL
CONDITIONS, ESPECIALLY THE
FOLLOWING:
*
a history of seizures or fits
*
brain disease
*
kidney disease
*
bowel problems
3. YOU HAVE ALLERGIES TO OTHER
ANTIBIOTICS, IN PARTICULAR,
PENICILLINS AND CEPHALOSPORINS
If you are allergic to any of these,
you may be allergic to
PRIMAXIN.
4. YOU HAVE ANY ALLERGIES TO ANY
OTHER MEDICINES OR ANY OTHER
SUBSTANCES, SUCH AS FOODS,
PRESERVATIVES OR DYES.
IF YOU HAVE NOT TOLD YOUR DOCTOR
ABOUT ANY OF THE ABOVE, TELL THEM
BEFORE YOU ARE GIVEN PRIMAXIN.
_TAKING OTHER MEDICINES_
TELL YOUR DOCTOR IF YOU ARE TAKING
ANY OTHER MEDICINES, INCLUD

Charakterystyka produktu

TEN-IV-102007  
1 

 PRODUCT INFORMATION 

 I.V. 
Infusion 

PRIMAXIN®             
(Imipenem-Cilastatin Sodium, MSD) 

NAME OF THE DRUG 

Imipenem and Cilastatin Sodium 

DESCRIPTION 

PRIMAXIN
® 
(Imipenem-Cilastatin Sodium, MSD) is a formulation of imipenem, a
thienamycin 
antibiotic, and cilastatin sodium, the inhibitor of the renal
dipeptidase, dehydropeptidase l, 
with sodium bicarbonate added as a buffer.   PRIMAXIN is a potent
broad spectrum 
antibacterial agent for intravenous administration. 

Imipenem (N-formimidoylthienamycin monohydrate) is a crystalline
derivative of 
thienamycin, which is produced by Streptomyces cattleya.   Its
chemical name is 
[5R-[5
α,6α(R*)]]-6-(1-hydroxyethyl)-3-[[2-[(iminomethyl)amino]ethyl]thio]
-
7-oxo-1-azabicyclo[3.2.0]hept -2-ene-2- carboxylic acid.   It is an
off-white, non-hygroscopic 
crystalline compound with a molecular weight of 299.37.   It is
sparingly soluble in water, and 
slightly soluble in methanol.   Its empirical formula is
 C12 H 17 N 3 O4 S and its structural 
formula is: 

 ® Registered Trademark of Merck & Co Inc, Whitehouse Station, NJ,
USA 
TEN-IV-102007  
2 

Cilastatin sodium is the sodium salt of a derivatised heptenoic acid.
Its chemical name is 
[Z,
7(R),2(S)]-7-[(2-amino-2-carboxyethyl)thio]-2-[[(2,2-dimethyl-cyclopropyl)carbonyl]amino]-
2-heptenoic acid monosodium salt.   It is an off-white to
yellowish-white, hygroscopic, 
amorphous compound with a molecular weight of 380.43.   It is very
soluble in water and in 
methanol.   Its empirical formula is C16 H25 N2 O 5 S.Na, and
its structural formula is: 

PRIMAXIN is buffered to provide solutions in th