PENICILLIN V POTASIUM tablet

Kraj: Stany Zjednoczone

Język: angielski

Źródło: NLM (National Library of Medicine)

Składnik aktywny:

PENICILLIN V POTASSIUM (UNII: 146T0TU1JB) (PENICILLIN V - UNII:Z61I075U2W)

Dostępny od:

Avera McKennan Hospital

INN (International Nazwa):

PENICILLIN V POTASSIUM

Skład:

PENICILLIN V 500 mg

Typ recepty:

PRESCRIPTION DRUG

Status autoryzacji:

Abbreviated New Drug Application

Charakterystyka produktu

PENICILLIN V POTASIUM- PENICILLIN V POTASIUM TABLET
AVERA MCKENNAN HOSPITAL
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PENICILLIN-VK
PENICILLIN V POTASSIUM TABLETS, USP
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of penicillin-VK
and other antibacterial drugs, penicillin-VK should be used only to
treat or prevent infections that are
proven or strongly suspected to be caused by bacteria.
DESCRIPTION
Penicillin V is the phenoxymethyl analog of penicillin G.
Penicillin V potassium is the potassium salt of penicillin V.
Molecular Formula: C
H O KN S Molecular Weight: 388.5
Penicillin -VK (Penicillin V Potassium Tablets USP), for oral
administration, contain 250 mg (400,000
units) or 500 mg (800,000 units) penicillin V. In addition, each
tablet contains the following inactive
ingredients: hydroxypropyl methylcellulose, magnesium stearate,
polyethylene glycol, povidone, talc,
and titanium dioxide.
CLINICAL PHARMACOLOGY
Penicillin V exerts a bactericidal action against penicillin-sensitive
microorganisms during the stage of
active multiplication. It acts through the inhibition of biosynthesis
of cell-wall mucopeptide. It is not
active against the penicillinase-producing bacteria, which include
many strains of staphylococci. The
drug exerts high _in vitro_ activity against staphylococci (except
penicillinase-producing strains),
streptococci (groups A, C, G, H, L and M), and pneumococci. Other
organisms sensitive _in vitro_ to
penicillin V are _Corynebacteriumdiphtheriae, Bacillus anthracis,
Clostridia, Actinomycesbovis,_
_Streptobacillusmoniliformis, Listeria monocytogenes, Leptospira, and
Neisseria gonorrhoeae._
_Treponemapallidum_ is extremely sensitive.
The potassium salt of penicillin V has the distinct advantage over
penicillin G in resistance to
inactivation by gastric acid. It may be given with meals; however,
blood levels are slightly higher when
the drug is given on an empty stomach. Average blood levels are two to
five times higher than the
levels following the same dose of oral penicillin G and also sh