Kraj: Australia
Język: angielski
Źródło: Department of Health (Therapeutic Goods Administration)
Bromocriptine mesylate
Novartis Pharmaceuticals Australia Pty Ltd
Medicine Registered
PARLODEL ® _bromocriptine mesylate_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Parlodel. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. The information in this leaflet was last updated on the date listed on the final page. More recent information on the medicine may be available. YOU SHOULD ENSURE THAT YOU SPEAK TO YOUR PHARMACIST OR DOCTOR TO OBTAIN THE MOST UP TO DATE INFORMATION ON THE MEDICINE. YOU CAN ALSO DOWNLOAD THE MOST UP TO DATE LEAFLET FROM WWW.NOVARTIS.COM.AU. Those updates may contain important information about the medicine and its use of which you should be aware. All medicines have risks and benefits. Your doctor has weighed the risks of you taking Parlodel against the benefits they expect it will provide. IF YOU HAVE ANY CONCERNS ABOUT THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT PARLODEL IS USED FOR Parlodel has several uses. It can be used for the following medical conditions: 1. Prevention/suppression of breast milk production (lactation) in women who cannot/do not breast- feed for medical reasons. If breast milk production has already begun, your doctor can advise you about other methods of stopping lactation. 2. Treatment of people who have high blood levels of a hormone called prolactin. This condition is sometimes caused by a type of tumour called a prolactinoma. 3. Treatment of acromegaly, a disease in which the body produces too much growth hormone. Parlodel treats this disease by reducing the level of growth hormone in the blood. 4. To relieve symptoms, such as shaking of the limbs, stiffness and slowness of movement, in people with Parkinson's disease. Parlodel is often used in combination with other medicines such as levodopa. Parlodel contains the active ingredient, bromocriptine. It belongs to a group of medicines known as the ergot alkaloids, derived from a Przeczytaj cały dokument
1 PARLODEL ® (BROMOCRIPTINE MESYLATE) NAME OF THE MEDICINE Active ingredient: Bromocriptine mesylate Chemical names: Ergotaman-3’,6’,18-trione, 2-bromo-12’-hydroxy-2’-(1-methylethyl)-5’- (2-methylpropyl)-, (5’α)-; 2-Bromoergocryptine monomethanesulphonate; 2-bromo- - ergocryptine mesylate; CAS Number: 22260-51-1 Chemical structure: H CH3 H H HN N Br O O N OH H CH 2 CH(CH 3 ) 2 O N H N C O CH(CH 3 ) 2 Chemical Formula: C 32 H 40 BrN 5 O 5 CH 4 O 3 S Molecular weight: 750.7 (mesylate salt); 654.5 (free base) DESCRIPTION Bromocriptine mesylate is a peptide ergot alkaloid, poorly soluble in water (<0.1% at 20 - 25 0 C). Freely soluble in methanol. Solubility in ethanol (70% v/v) is 75%. Parlodel tablets and capsules contain bromocriptine mesylate. EXCIPIENTS Tablets: magnesium stearate, silica colloidal anhydrous, maize starch, disodium edetate, maleic acid, and lactose. Capsules: magnesium stearate, silica colloidal anhydrous, maize starch, maleic acid, lactose, gelatin, and titanium dioxide. The 5 mg capsules also contain shellac, red iron oxide CI77491, and indigo carmine CI73015. 2 PHARMACOLOGY Parlodel has a pharmacological spectrum unlike that of most classical ergot compounds, having no uterotonic and little vasoconstrictor activity. Its principal effects derive from dopaminergic receptor stimulant activity. It inhibits prolactin secretion and the effect can be demonstrated after single or repeated oral administration of the Przeczytaj cały dokument