Kraj: Australia
Język: angielski
Źródło: Department of Health (Therapeutic Goods Administration)
Rabeprazole sodium
Arrow Pharma Pty Ltd
Rabeprazole sodium
PARBEZOL CONSUMER MEDICINE INFORMATION Ver 1.1 Page 1 of 5 PARBEZOL 10 & 20 Rabeprazole sodium CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about PARBEZOL tablets. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking PARBEZOL against the benefits it is expected to have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE . You may need to read it again. WHAT PARBEZOL IS USED FOR The name of your medicine is PARBEZOL TM . It contains the active ingredient rabeprazole sodium. WHAT IT DOES This medicine is used to treat, _- Reflux Oesophagitis _ _- Peptic Ulcers _ _- Chronic Gastritis _ _ _ _Reflux Oesophagitis:_ This medicine is used to treat reflux oesophagitis or reflux disease. This can be caused by food and acid from the stomach flowing the wrong way (reflux) back up the food pipe, also known as the oesophagus. Reflux can cause a burning sensation in the chest rising up to the throat, also known as heartburn. This medicine is also used to help stop reflux oesophagitis from coming back or relapsing. _ _ _Peptic Ulcers: _ This medicine is used to treat peptic ulcers. Depending on the position of the ulcer, it is called a gastric or duodenal ulcer. A gastric ulcer occurs in the stomach. A duodenal ulcer occurs in the duodenum which is the tube leading out of the stomach. These ulcers can be caused by too much acid being made in the stomach. Most people who have a peptic ulcer also have a bacteria called Helicobacter pylori in their stomach. Your doctor may also prescribe a course of antibiotics (clarithromycin and amoxycillin) for you. When PARBEZOL is taken with antibiotics, the combination therapy will kill the Helicobacter pylori and let your ulcer heal. _ _ _Chronic Gastritis: _ The presence of the bacteria Helicobacter pylori may cau Przeczytaj cały dokument
PARBEZOL- Product Information Page 1 of 13 PRODUCT INFORMATION PARBEZOL 10 (10 MG RABEPRAZOLE SODIUM TABLETS) PARBEZOL 20 (20 MG RABEPRAZOLE SODIUM TABLETS) NAME OF THE MEDICINE The name of the medicine is rabeprazole as rabeprazole sodium. The chemical name for rabeprazole sodium is (±) 2-[{4-(3-methoxypropoxy)-3- methylpyridin-2- yl}-methylsulphinyl]-1H-benzimidazole sodium. Rabeprazole has one chiral centre and is a racemate of two enantiomers. It has the following structural formula: CAS Registration No.: CAS-117976-89-3 (rabeprazole) CAS-117976-90-6 (rabeprazole sodium) DESCRIPTION Rabeprazole sodium is a substituted benzimidazole and belongs to the class of proton pump inhibitors. It is a white to off-white hydroscopic powder. Its solubility in water is pH dependent, being very soluble in water at pH 9 to 11, and only slightly soluble in water at pH 8. It is very soluble in methanol, freely soluble in dichloromethane and practically insoluble in hexane. PARBEZOL is available as enteric coated tablets containing 10 mg rabeprazole sodium (equivalent to 9.42 mg rabeprazole) or 20 mg rabeprazole sodium (equivalent to 18.85 mg rabeprazole). PARBEZOL tablets contain the inactive ingredients mannitol, heavy magnesium oxide, light magnesium oxide, hydroxypropylcellulose, crospovidone, magnesium stearate, ethylcellulose, hypromellose phthalate, diacetylated monoglycerides, purified talc and titanium dioxide. The 20 mg tablet also contains iron oxide yellow. PHARMACOLOGY Rabeprazole sodium suppresses gastric acid secretion by the specific inhibition of the H + /K + - ATPase enzyme (proton pump) at the secretory surface of the gastric parietal cell thereby blocking the final step of acid production. This effect is dose-related and leads to inhibition of both basal and stimulated acid secretion irrespective of the stimulus. Animal studies indicate that after administration, rabeprazole sodium rapidly disappears from both the plasma and gastric mucosa. PARBEZOL- Product Information Page 2 of 13 PHARMACODYNAMICS _ _ _An Przeczytaj cały dokument