Olanzapine RBX

Kraj: Australia

Język: angielski

Źródło: Department of Health (Therapeutic Goods Administration)

Składnik aktywny:

Olanzapine

Dostępny od:

Ranbaxy Australia Pty Ltd

Klasa:

Medicine Registered

Ulotka dla pacjenta

OLANZAPINE RBX CMI V5 Sep 2013  

                              Page 1 of 10 

OLANZAPINE RBX TABLETS 
Olanzapine  
CONSUMER MEDICINE INFORMATION 
WHAT IS IN THIS LEAFLET  
This leaflet answers some common questions about OLANZAPINE RBX.  
It does not contain all the available information. 
It does not take the place of talking to your doctor or pharmacist. 
This leaflet was last updated on the date at the end of this
leaflet. 
More recent information may be available. The latest Consumer
Medicine 
Information is available from 
https://www.ebs.tga.gov.au/
   and may 
contain important information about the medicine and its use of
which 
you should be aware. 
All medicines have risks and benefits. Your doctor has weighed the 
risks of you taking OLANZAPINE RBX  against the benefits it
is  expected 
to have for you. 
IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR 
PHARMACIST. 
KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it
again. 
WHAT OLANZAPINE RBX IS USED FOR 
The name of your medicine is  OLANZAPINE RBX.  OLANZAPINE
RBX  contains 
olanzapine as the  active ingredient. Olanzapine  belong  to a
group of 
medicines called antipsychotics. OLANZAPINE RBX  helps to correct 
chemical imbalances in the brain which may cause mental illness.  
OLANZAPINE RBX  is  used to treat symptoms of schizophrenia and
related 
psychoses.  Schizophrenia is a mental illness with disturbances
in 
thinking, feeling and behavior.   
OLANZAPINE RBX  alone, or in combination with lithium or
valproate, is 
also  used for the short-term treatment  of acute manic
episodes 
associated with bipolar I disorder,  an

Charakterystyka produktu

OLANZAPINE RBX PI V6                            

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OLANZAPINE RBX

OLANZAPINE TABLETS 2.5/5/7.5/10 MG 

NAME OF THE MEDICINE 
_ _
_Olanzapine _

Structural formula: 

Molecular formula: C
17
H
20
N
4
S 
Chemical name : 2-Methyl-4-(4-methyl-1-piperazinyl)-10_H_-thieno[2,3-_b_][1,5] 
benzodiazepine 
Molecular weight: 312.44 
CAS Number: 132539-06-1 

DESCRIPTION 

Olanzapine is a yellow crystalline solid that
is practically insoluble in water. Each tablet 
of OLANZAPINE RBX contains olanzapine 2.5 mg, 5.0
mg, 7.5 mg or 10 mg.  

OLANZAPINE RBX contains the following inactive ingredients: lactose anhydrous, 
microcrystalline cellulose, hydroxypropylcellulose and magnesium
stearate. 

PHARMACOLOGY 
_ _
PHARMACODYNAMIC PROPERTIES 

Olanzapine is an atypical antipsychotic, antimanic and
mood-stabilising agent that 
demonstrates a broad pharmacological profile across a
number of receptor systems.  
In preclinical studies, olanzapine exhibited
a range of receptor affinities (Ki <100 
nanomol) for serotonin 5HT
2A/2C
, 5HT
3
, 5HT
6
; dopamine D
1
, D
2
, D
3
, D
4
, D
5
; cholinergic 
muscarinic receptors m
1
 to m
5
; alpha
1
-adrenergic; and histamine H
1
-receptors. Animal 
behavioural studies with olanzapine indicated 5HT, dopamine and
cholinergic 
antagonism consistent with the receptor-binding profile.
Olanzapine demonstrated a 
greater _in vitro_ affinity for serotonin 5HT
2
 than dopamine D
2
-receptors and in _in vivo_ 
models, greater 5HT
2
 than D
2
 activity. Electrophysiological studies demonstrated that 
olanzapine
selectively reduced the firing of mesolimbic (Al0) dopaminergic neurons, 
OLANZAPINE RBX PI V6