KETAMINE HYDROCHLORIDE injection

Kraj: Stany Zjednoczone

Język: angielski

Źródło: NLM (National Library of Medicine)

Składnik aktywny:

ketamine hydrochloride (UNII: O18YUO0I83) (ketamine - UNII:690G0D6V8H)

Dostępny od:

Par Pharmaceutical Inc.

INN (International Nazwa):

ketamine hydrochloride

Skład:

ketamine 10 mg in 1 mL

Typ recepty:

PRESCRIPTION DRUG

Status autoryzacji:

New Drug Application Authorized Generic

Charakterystyka produktu

KETAMINE HYDROCHLORIDE- KETAMINE HYDROCHLORIDE INJECTION
PAR PHARMACEUTICAL INC.
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KETAMINE HYDROCHLORIDE INJECTION, USP
CIII
SPECIAL NOTE
EMERGENCE REACTIONS HAVE OCCURRED IN APPROXIMATELY 12 PERCENT OF
PATIENTS.
THE PSYCHOLOGICAL MANIFESTATIONS VARY IN SEVERITY BETWEEN PLEASANT
DREAM-LIKE STATES, VIVID IMAGERY, HALLUCINATIONS, AND EMERGENCE
DELIRIUM.
IN SOME CASES THESE STATES HAVE BEEN ACCOMPANIED BY CONFUSION,
EXCITEMENT, AND IRRATIONAL BEHAVIOR WHICH A FEW PATIENTS RECALL AS AN
UNPLEASANT EXPERIENCE. THE DURATION ORDINARILY IS NO MORE THAN A FEW
HOURS; IN A FEW CASES, HOWEVER, RECURRENCES HAVE TAKEN PLACE UP TO 24
HOURS POSTOPERATIVELY. NO RESIDUAL PSYCHOLOGICAL EFFECTS ARE KNOWN TO
HAVE RESULTED FROM USE OF KETAMINE HYDROCHLORIDE INJECTION.
THE INCIDENCE OF THESE EMERGENCE PHENOMENA IS LEAST IN THE ELDERLY
(OVER
65 YEARS OF AGE) PATIENT. ALSO, THEY ARE LESS FREQUENT WHEN THE DRUG
IS
GIVEN INTRAMUSCULARLY AND THE INCIDENCE IS REDUCED AS EXPERIENCE WITH
THE DRUG IS GAINED.
THE INCIDENCE OF PSYCHOLOGICAL MANIFESTATIONS DURING EMERGENCE,
PARTICULARLY DREAM-LIKE OBSERVATIONS AND EMERGENCE DELIRIUM, MAY BE
REDUCED BY USING LOWER RECOMMENDED DOSAGES OF KETAMINE HYDROCHLORIDE
INJECTION IN CONJUNCTION WITH INTRAVENOUS DIAZEPAM DURING INDUCTION
AND
MAINTENANCE OF ANESTHESIA. (See DOSAGE AND ADMINISTRATION Section.)
ALSO,
THESE REACTIONS MAY BE REDUCED IF VERBAL, TACTILE, AND VISUAL
STIMULATION
OF THE PATIENT IS MINIMIZED DURING THE RECOVERY PERIOD. THIS DOES NOT
PRECLUDE THE MONITORING OF VITAL SIGNS.
IN ORDER TO TERMINATE A SEVERE EMERGENCE REACTION, THE USE OF A SMALL
HYPNOTIC DOSE OF A SHORT-ACTING OR ULTRA SHORT-ACTING BARBITURATE MAY
BE REQUIRED.
WHEN KETAMINE HYDROCHLORIDE INJECTION IS USED ON AN OUTPATIENT BASIS,
THE PATIENT SHOULD NOT BE RELEASED UNTIL RECOVERY FROM ANESTHESIA IS
COMPLETE AND THEN SHOULD BE ACCOMPANIED BY A RESPONSIBLE ADULT.
DESCRIPTION
Ketamine hydrochloride is a nonbarbiturate anesthetic chemically
designated _dl_ 2-(0-chlorophenyl)-2-
(methylamino) cyclohexanone hydrochloride. It