ISOTHESIA - isoflurane liquid

Kraj: Stany Zjednoczone

Język: angielski

Źródło: NLM (National Library of Medicine)

Składnik aktywny:

ISOFLURANE (UNII: CYS9AKD70P) (ISOFLURANE - UNII:CYS9AKD70P)

Dostępny od:

Butler Animal Health Supply, LLC

INN (International Nazwa):

ISOFLURANE

Skład:

ISOFLURANE 1 mL in 1 mL

Droga podania:

RESPIRATORY (INHALATION)

Typ recepty:

PRESCRIPTION

Wskazania:

Isothesia is used for induction and maintenance of general anesthesia in horses and dogs. Isothesia is contraindicated in horses and dogs with known sensitivity to isoflurane or to other halogenated agents.

Podsumowanie produktu:

Isothesia is packaged in 100 mL (NDC 11695-6776-1) and 250 mL (NDC 11695-6776-2) amber-colored bottle. Storage: Store at room temperature 20o to 25o C (68o to 77o F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].

Status autoryzacji:

Abbreviated New Animal Drug Application

Charakterystyka produktu

ISOTHESIA - ISOFLURANE LIQUID
BUTLER ANIMAL HEALTH SUPPLY, LLC
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CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
Warning: Not for use in horses intended for food.
DESCRIPTION
Isothesia is a nonflammable, nonexplosive general inhalation
anesthetic agent. Its chemical name is l-
chloro-2,2,2-trifluoroethyldifluoromethyl ether, and its structural
formula
is:
Each mL contains 99.9% isoflurane.
Some physical constants are:
Molecular weight
184.5
Boiling point at 760 mm Hg
48.5° C (uncorr.)
Refractive index
1.2990-1.3005
Specific gravity 25°/25° C
1.496
Vapor pressure in mm Hg**20° C238
25° C295
30° C367
35° C450
**Equation for vapor pressure calculation:
log
_P_
= A + B/T
where: A = 8.056
B = -1664.58
T = °C + 273.16 (Kelvin)
Partition coefficients at 37° C:
Water/gas 0.61
Blood/gas1.43
Oil/gas
90.8
Partition coefficients at 25° C - rubber and plastic
Conductive rubber/gas
62.0
Butyl rubber/gas
75.0
Polyvinyl chloride/gas
110.0
Polyethylene/gas
~2.0
Polyurethane/gas
~1.4
Polyolefin/gas
~1.1
Butyl acetate/gas
~2.5
Purity by gas chromatography
>99.9%
Lower limit of flammability in oxygen or
nitrous oxide at 9 joules/sec. and 23° C
None
Lower limit of flammability in oxygen or nitrous oxide at
900 joules/sec. and 23° C
Greater than useful concentration in
anesthesia.
MAC (Minimum Alveolar Concentration) is 1.31% in horses and 1.28% in
dogs.
Isoflurane is a clear, colorless, stable liquid containing no
additives or chemical stabilizers. Isoflurane
has a mildly pungent, musty, ethereal odor. Samples stored in indirect
sunlight in clear, colorless glass
for five years, as well as samples directly exposed for 30 hours to a
2 amp, 115 volt, 60 cycle long
wave U.V. light were unchanged in composition as determined by gas
chromatography. Isoflurane in
one normal sodium methoxide-methanol solution, a strong base, for over
six months consumed
essentially no alkali, indicative of strong base stability. Isoflurane
does not decompose in the presence
of soda lime (at