Kraj: Stany Zjednoczone
Język: angielski
Źródło: NLM (National Library of Medicine)
HYDROXYZINE HYDROCHLORIDE (UNII: 76755771U3) (HYDROXYZINE - UNII:30S50YM8OG)
A-S Medication Solutions
HYDROXYZINE HYDROCHLORIDE
HYDROXYZINE HYDROCHLORIDE 50 mg
ORAL
PRESCRIPTION DRUG
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic conditions such as chronic urticaria and atopic and contact dermatoses, and in histamine-mediated pruritus. As a sedative when used as premedication and following general anesthesia, hydrOXYzine may potentiate meperidine and barbiturates , so their use in pre-anesthetic adjunctive therapy should be modified on an individual basis. Atropine and other belladonna alkaloids are not affected by the drug. HydrOXYzine is not known to interfere with the action of digitalis in any way and it may be used concurrently with this agent. The effectiveness of hydrOXYzine as an antianxiety agent for long-term use, that is more than 4 months, has not been assessed by systematic clinical studies. The physician should reassess periodically the usefulness of the drug for the individual patient. Oral hydrOXYzine hydrochloride i
Product: 50090-2070 Product: 50090-2930 NDC: 50090-2930-1 28 TABLET, FILM COATED in a BOTTLE
Abbreviated New Drug Application
HYDROXYZINE HYDROCHLORIDE- HYDROXYZINE HYDROCHLORIDE TABLET, FILM COATED A-S MEDICATION SOLUTIONS ---------- HYDROXYZINE HYDROCHLORIDE TABLETS, USP RX ONLY DESCRIPTION HydrOXYzine hydrochloride has the chemical name of 2-[2-[4-(_p_-Chloro- -phenylbenzyl)-1- piperazinyl] ethoxy] ethanol dihydrochloride. HydrOXYzine hydrochloride occurs as a white, odorless powder which is very soluble in water. Each tablet for oral administration contains 10 mg, 25 mg and 50 mg hydrOXYzine HCl. Inactive ingredients include colloidal silicon dioxide, crospovidone, dibasic calcium phosphate anhydrous, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium starch glycolate and Opadry Beige (Hypromellose, Titanium dioxide, Iron oxide yellow, PEG 400, Iron oxide red, and Polysorbate 80). CLINICAL PHARMACOLOGY HydrOXYzine hydrochloride is unrelated chemically to the phenothiazines, reserpine, meprobamate, or the benzodiazepines. HydrOXYzine hydrochloride is not a cortical depressant, but its action may be due to a suppression of activity in certain key regions of the subcortical area of the central nervous system. Primary skeletal muscle relaxation has been demonstrated experimentally. Bronchodilator activity, and antihistaminic and analgesic effects have been demonstrated experimentally and confirmed clinically. An antiemetic effect, both by the apomorphine test and the veriloid test, has been demonstrated. Pharmacological and clinical studies indicate that hydrOXYzine in therapeutic dosage does not increase gastric secretion or acidity and in most cases has mild antisecretory activity. HydrOXYzine is rapidly absorbed from the gastrointestinal tract and hydrOXYzine hydrochloride’s clinical effects are usually noted within 15 to 30 minutes after oral administration. INDICATIONS AND USAGE INDICATIONS AND USAGE For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested. Useful in the management of pruritus due to allergic co Przeczytaj cały dokument