HYDROVAL OINTMENT 0.2%

Kraj: Kanada

Język: angielski

Źródło: Health Canada

Składnik aktywny:

HYDROCORTISONE VALERATE

Dostępny od:

TAROPHARMA, A DIVISION OF TARO PHARMACEUTICALS INC.

Kod ATC:

D07AA02

INN (International Nazwa):

HYDROCORTISONE

Dawkowanie:

0.2%

Forma farmaceutyczna:

OINTMENT

Skład:

HYDROCORTISONE VALERATE 0.2%

Droga podania:

TOPICAL

Sztuk w opakowaniu:

60G

Typ recepty:

Prescription

Dziedzina terapeutyczna:

ANTI-INFLAMMATORY AGENTS

Podsumowanie produktu:

Active ingredient group (AIG) number: 0112513001; AHFS:

Status autoryzacji:

APPROVED

Data autoryzacji:

2003-09-03

Charakterystyka produktu

PRODUCT MONOGRAPH
HydroVal
(Hydrocortisone Valerate)
Cream & Ointment 0.2 %
Topical Corticosteroid
TaroPharma
Preparation Date:
A Division of
Taro Pharmaceuticals Inc.
Sept 02, 2003
130 East Drive
Brampton, Ontario
Revision Date:
L6T 1C1
August 6, 2003
Control #086230
1
PRODUCT MONOGRAPH
HydroVal
Cream & Ointment 0.2 %
(Hydrocortisone Valerate Cream, USP)
(Hydrocortisone Valerate Ointment, USP)
Topical Corticosteroid
ACTIONS AND CLINICAL PHARMACOLOGY
HydroVal 0.2% (hydrocortisone valerate) cream and ointment are
moderately
potent non-fluorinated, topical corticosteroids. Topical
corticosteroids are
synthetic derivatives of cortisone which are effective when applied
locally to
control
many
types
of
inflammatory,
allergic
and
pruritic
dermatoses.
Modifications to the chemical structure such as fluorination,
generally enhances
both anti-inflammatory activity and increases the likelihood of
adverse effects.
The mechanism of anti-inflammatory activity of topical corticosteroids
is
generally unclear. However, corticosteroids are thought to induce
phospholipase
A2 inhibitor proteins, preventing arachidonic acid release and the
biosynthesis
of potent mediators of inflammation.
Topical
corticosteroids
are
primarily
effective
because
of
their
anti-
inflammatory, anti-pruritic and vasoconstrictive actions.
2
Topical absorption of corticosteroids follow the same pharmacologic
fate as
systemically administered doses: corticosteroids in the circulation
are bound to
plasma proteins, although the fluorinated compounds are bound to a
lesser
degree,
accounting
for
their
increased
potency
compared
to
natural
corticosteroids.
It is generally known that steroid hormones are metabolized
predominantly in the
liver and to a lesser extent in the kidney, intestines, spleen,
muscles and other
tissues and then excreted in the urine as conjugates.
INDICATIONS AND CLINICAL USE
HydroVal 0.2% (hydrocortisone valerate) cream and ointment are
indicated for
topical therapy of acute and chronic corticosteroid responsive
dermatoses, where
an anti-in