FLUIMUCIL A 600 EFFERVESCENT TABLET 600MG (Revised Formula)

Kraj: Singapur

Język: angielski

Źródło: HSA (Health Sciences Authority)

Składnik aktywny:

ACETYLCYSTEINE

Dostępny od:

UNITED ITALIAN TRADING CORPORATION (PRIVATE) LIMITED

Kod ATC:

R05CB01

Dawkowanie:

600 mg

Forma farmaceutyczna:

TABLET

Skład:

ACETYLCYSTEINE 600 mg

Droga podania:

ORAL

Typ recepty:

Pharmacy Only

Wyprodukowano przez:

ZAMBON SWITZERLAND LTD

Status autoryzacji:

ACTIVE

Data autoryzacji:

1993-08-17

Ulotka dla pacjenta

_Package Leaflet _
_ _
FLUIMUCIL® A 600 EFFERVESCENT TABLETS 600MG
FLUIMUCIL® GRANULES 600MG/SACHET
FOR ORAL USE PHARMACOLOGICAL PROPERTIES
Acetylcysteine (NAC), the active ingredient of Fluimucil® A
Effervescent Tablets 600mg and
Fluimucil® Granules 600mg exerts an intense
mucolytic-fluidifying
action on mucous and
mucopurulent secretions, by depolymerizing the mucoproteic complexes
and the nucleic
acids which confer viscosity to the vitreous and purulent component of
the sputum and of
other secretions.
Additional properties are: reduction of induced hyperplasia of mucous
cells, increase in
surfactant production by stimulation of type II pneumocytes,
stimulation of mucociliary
activity, leading to improved mucociliary clearance.
Furthermore, NAC, exerts a direct antioxidant action, being provided
with a free thiol (-SH
nucleophilic) group, which is able to interact directly with the
electrophilic groups of the
oxidant radicals. Of particular interest is the finding that NAC
protects the
∝
-1-antitrypsin,
enzyme inhibitor of elastase, from the inactivation due to the action
of hypochlorous acid
(HOCI), a powerful oxidant agent produced by the myeloperoxidase
enzyme of activated
phagocytes.
Furthermore,
Acetylcysteine exerts in addition an indirect antioxidant effect
through its role as GSH precursor
. Inside the cell, NAC is deacetylized, forming L-cysteine, an
amino acid indispensable for the glutathione synthesis (GSH). GSH is a
highly reactive
tripeptide, found ubiquitously in the various tissues of animals and
is essential for the
maintenance
of
functional
capacity
as
well
as
cellular
morphological
integrity,
as
it
represents the most important protective endocellular mechanism
against oxidant radicals,
either of external or internal nature, as well as towards numerous
cytotoxic substances.
NAC plays a role of primary importance in the maintenance of adequate
GSH levels thus
contributing to the cellular protections from harmful agents which,
through progressive GSH
depletion, would be able to express th