Kraj: Stany Zjednoczone
Język: angielski
Źródło: NLM (National Library of Medicine)
ephedrine sulfate (UNII: U6X61U5ZEG) (ephedrine - UNII:GN83C131XS)
Andersen Pharma LLC
ephedrine sulfate
ephedrine sulfate 50 mg in 1 mL
PRESCRIPTION DRUG
unapproved drug other
EPHEDRINE SULFATE- EPHEDRINE SULFATE INJECTION, SOLUTION ANDERSEN PHARMA LLC _Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been_ _approved by FDA. For further information about unapproved drugs, click here._ ---------- EPHEDRINE SULFATE INJECTION, USP (50 MG/ML) PRES ERVATIVE-FREE SINGLE DOSE VIAL PROTECT FROM LIGHT. KEEP VIALS IN TRAY UNTIL TIME OF USE. DESCRIPTION Ephedrine Sulfate Injection, USP is a sterile, nonpyrogenic solution containing ephedrine sulfate 50 mg/mL in water for injection. It is administered by subcutaneous, intramuscular or intravenous injection as an adrenergic agent. The solution contains no bacteriostat, antimicrobial agent or added buffer. The pH is 5.3 (4.5 to 7.0). The osmolar concentration of the 5% solution is 0.35 mOsmol/mL (calc.). Ephedrine Sulfate, USP is a sympathomimetic amine chemically designated α-[1-(methylamino) ethyl] benzenemethanol sulfate (2:1)(salt). It has the following structural formula: CLINICAL PHARMACOLOGY Therapeutic doses of ephedrine produce mainly relaxation of smooth muscle and, if norepinephrine stores are intact, cardiac stimulation and increased systolic and usually increased diastolic blood pressure. Its vasopressor effect results largely from increased cardiac output and to a lesser extent from peripheral vasoconstriction. Pressor responses to parenteral ephedrine are slower but more prolonged than those produced by epinephrine. Ephedrine stimulates both alpha and beta receptors and its peripheral actions are due partly to norepinephrine release and partly to direct effect on receptors. Ephedrine may deplete norepinephrine stores in sympathetic nerve endings, so that tachyphylaxis to cardiac and pressor effects of the drug may develop. Central nervous system effects are similar to those of amphetamine drugs but less pronounced. The central effects of ephedrine are overshadowed to a large extent by its peripheral actions. Glycogenolysis in the liver is increased by ephedrine but not as much as by Przeczytaj cały dokument