Dermcare Malaseb Medicated Shampoo

Kraj: Malezja

Język: angielski

Źródło: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Składnik aktywny:

Chlorhexidine Gluconate; MICONAZOLE NITRATE

Dostępny od:

PET ARCADE SDN BHD

INN (International Nazwa):

Chlorhexidine Gluconate; MICONAZOLE NITRATE

Wyprodukowano przez:

Ensign Laboratories Pty Limited

Charakterystyka produktu

PACKAGE INSERT
Product Name
DERMCARE MALASEB® MEDICATED SHAMPOO
Active Substance
Chlorhexidine gluconate 20g/L
Miconazole nitrate 20g/L
Description
A
topical
keratolytic,
antibacterical,
antifungal
and
antipruritic
shampoo for dogs and cats.
Pharmacodynamics/
Pharmacokinetics
The
primary
pharmacodynamic
action
of the
active
substances
is
antimicrobial. Miconazole is an imidazole with market antifungal and
anti-yeast activity. The fungicidal action of the imidazole compounds,
including miconazole, is by inhibition of ergosterol incorporation
into
membranes,
so
increasing
concentrations
of
cytotoxic
hydrogen
peroxide accumulate within the fungal cell wall. Chlorhexidine is an
antiseptic with broad spectrum activity. It is effective against many
Gram negative and Gram positive bacteria. Chlorhexidine is absorbed
onto bacterial membranes and interferes with membrane functions
such as the sodium and potassium ATPase pump. At bacteriostatic
concentrations,
lysis of the
membrane occurs,
but
at
bactericidal
concentrations,
coagulation
of
the
cytoplasm
occurs
without
cell
rupture.
Chlorhexidine
gluconate
and
miconazole
nitrate
possess
virtually no secondary pharmacodynamics properties.
Miconazole is poorly absorbed from the skin and gastrointestinal
tract.
Systemically available miconazole is metabolised in the liver and the
metabolites
excreted
in
the
urine
and
faeces.
Therefore,
the
combination of poor absorption and hepatic metabolism following
topical application of this drug to dogs would not result in
significant
systemic concentrations of the drug either by absorption through the
skin or by ingestion if the dog licked its coat or a lesion.
Environmental
Not applicable.
Indication
For the treatment of seborrhoeic dermatitis associated with infectious
by
_Staphylococcus _
_intermedius_,
_Malassezia _
_(Pityrosporum) _
_pachydermatis_
and
an
aid
in
the
treatment
of
dermatophyte
(Ringworm)
infections
due
to
_Microsporum _
_canis_,
_Microsporum _
_gypseum_
and
_Trichophyton _
_mentagrophytes_
in
dogs
and
cats
by
decrea