Kraj: Australia
Język: angielski
Źródło: Department of Health (Therapeutic Goods Administration)
Amlodipine besilate
Actavis Pty Ltd
Medicine Registered
_Consumer Medicine Information _ AMLODIPINE-GA CMI v3 080910 Page 1 of 10 AMLODIPINE-GA TABLETS AMLODIPINE BESILATE CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about Amlodipine-GA tablets. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking Amlodipine- GA against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT AMLODIPINE-GA TABLETS ARE USED FOR Amlodipine-GA tablets are used to lower high blood pressure (hypertension). There are usually no symptoms of hypertension. The only way of knowing that you have hypertension is to have your blood pressure checked on a regular basis. If high blood pressure is not treated it can lead to serious health problems. Amlodipine-GA tablets belong to a group of medicines called calcium channel blockers or calcium ion antagonists. They work by widening your blood vessels, making it easier for your heart to pump blood around the body and help increase the supply of blood and oxygen to your heart. Calcium channel blockers do not change the amount of calcium in your blood or bones. _Consumer Medicine Information _ AMLODIPINE-GA CMI v3 080910 Page 2 of 10 Amlodipine-GA tablets are also used to treat angina pectoris. Angina is a pa Przeczytaj cały dokument
PRODUCT INFORMATION AMLODIPINE – GA TABLETS NAME OF THE MEDICINE: AMLODIPINE BESILATE. Amlodipine besilate is a dihydropyridine derivative, and has the following chemical name: 3-Ethyl 5-methyl (4 _RS_)-2-[(2-aminoethoxy) methyl]-4-(2-chlorophenyl)-6-methyl-1, 4-dihydropyridine-3, 5-dicarboxylate benzenesulphonate. CAS NUMBER: 111470-99-6 DESCRIPTION: Empirical formula: C 20 H 25 ClN 2 O 5 .C 6 H 6 O 3 S Molecular weight of 567.1 Amlodipine besilate is a white crystalline powder and is freely soluble in methanol slightly soluble in water, 2-propanol and sparingly soluble in ethanol. In addition to amlodipine besilate, each Amlodipine-GA tablet contains the following inactive ingredients: cellulose microcrystalline; calcium hydrogen phosphate anhydrous; sodium starch glycollate (Type A); magnesium stearate. ACTIONS: Amlodipine is a calcium ion influx inhibitor (slow channel blocker or calcium ion antagonist) and inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. Experimental data suggest that amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects can be detected _in vitro_ but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound Product Information _ _ Page 2 of 11 Amlodipine-GA v3 PI 080715 (pKa=8.6), and its kinetic Przeczytaj cały dokument