YSP CLOMIPHENE TABLET 50mg

Land: Malaysia

Språk: engelsk

Kilde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktiv ingrediens:

CLOMIPHENE CITRATE

Tilgjengelig fra:

Y.S.P. INDUSTRIES (M) SDN. BHD.

INN (International Name):

CLOMIPHENE CITRATE

Enheter i pakken:

10`s x 10 Tablets

Produsert av:

Y.S.P. INDUSTRIES (M) SDN. BHD.

Preparatomtale

YSP CLOMIPHENE TABLET 50mg
Clomiphene Citrate is a synthetic, non-steroidal triphenylethylene
estrogen derivative. It is the drug most widely
used for treatment of anovulation. Clomiphene has become a valuable
drug for treating anovulatory infertility since
its discovery in 1961.
INGREDIENT(S):
Each tablet contains:
Clomiphene Citrate
........................................................... 50mg
PHARMACODYNAMICS:
1. Clomiphene is chemically related to chlorotrianisene. It stimulates
the secretion of pituitary gonadotrophic
hormones probably by blocking the effect of estrogens at receptor
sites in the hypothalamus and pituitary.
2. Clomiphene is the drug of choice for anovulatory or oligo-ovulatory
women who have endogenous estrogen
activity and an intact hypothalamic-pituitary-ovarian axis. Most
anovulatory patients respond promptly to low
dosages of Clomiphene Citrate. Approximately 75% of patients ovulate
following treatment with the 50mg/day or
100mg/day regimen. Moreover, side effects are mild.
PHARMACOKINETICS:
Clomiphene is readily absorbed orally in human, and is excreted
principally in the feces. Due to enterohepatic
recirculation the biological half-life is reported to be 5 days.
ROUTE OF ADMINISTRATION:
To be taken orally.
INDICATION(S):
Induction of ovulation in patients with persistent ovulatory
dysfunction who desire pregnancy. It should only be used
after careful evaluation has established ovulatory dysfunction as the
cause of infertility.
DOSAGE AND ADMINISTRATION:
The usual dose by mouth is 50mg daily for 5 days, starting on or about
the 5th day of the menstrual cycle or at any
time if there is amenorrhea. If ovulation does not occur, a course of
100mg daily for 5 days may be started. This
course may begin as early as 30 days after the previous one. Do not
increase dosage or duration of therapy beyond
100mg/day for 5 days. The majority of patients who respond to do so
during the first course of therapy, and 3
courses constitute an adequate therapeutic trial. If ovulatory menses
do not occur, th