Land: Malaysia
Språk: engelsk
Kilde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
TYLOSIN
Vemedim Sdn Bhd
TYLOSIN
100 ml
VEMEDIM VETERINARY DRUGS AND PROBIOTICS CO., LTD (VEMEDIM ANIMAL HEALTH)
Manufactured by: VEMEDIM VETERINARY DRUGS AND PROBIOTICS CO., LTD (Vemedim Animal Health) Song Hau Industrial Zone, Chau Thanh District, Hau Giang Province, Vietnam Product Registration Holder: VEMEDIM SDN BHD 15, Jalan USJ 1/31, 47600 Subang Jaya Selangor, Darul Ehsan, Malaysia COMPOSITION: Each ml contains: Tylosin …………………….….…..…… 50 mg With 4.0% (v/v) Benzyl Alcohol as a preservative DESCRIPTION The finished product is yellow transparent solution. TARGET SPECIES Cattle (Beef, calves, dairy, non-lactating), swine PHARMACODYNAMICS Tylosin is a macrolide antibiotic and exerts its antibiotic activity by a similar mechanism to other macrolides i.e. binding to the 50S fraction of the ribosomes resulting in an inhibition of the synthesis of proteins. Tylosin has mainly a bacteriostatic activity. Tylosin has an antibiotic effect against Gram positive cocci (Staphylococci, Streptococci), Gram positive bacilli (_Erysipelothrix_ spp.), some Gram-negative bacilli (_Pasteurella_ spp., _Mannheimia_ spp.) and _Mycoplasma_ spp. Resistance to macrolides is usually plasmid- mediated but modification of ribosomes may occur through chromosomal mutation. Resistance can occur by i) decreased entry into bacteria (most common with the gram- negative bacteria), ii) synthesis of bacterial enzymes that hydrolyse the drug and, iii) modification of the target (the ribosome). This latter resistance type may also lead to cross-resistance with other antibiotics that preferentially bind to bacterial ribosome. Gram-negative anaerobic bacteria are often resistant. Resistance of _ Brachyspira hyodysenteriae _ to tylosin has been reported. PHARMACOKINETICS Absorption: Following intramuscular injection, tylosin blood levels peak 1-2 hours post- injection. Duration of activity is approximately 12 hours. Distribution, Biotransformation and Elimination: Tylosin levels of 1.4 to 1.6 and 2.2 to 6.7μg/ml were recorded in serum and lung tissue respectively following intramuscular injection of 8.8 mg/kg bodyweight in pigs. Measur Les hele dokumentet